| Project/Area Number |
15K15300
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本多 彰 東京医科大学, 医学部, 教授 (10468639)
宮崎 照雄 東京医科大学, 医学部, 講師 (60532687)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 胆汁酸 / ミュリコール酸 / マウス |
|---|
| Outline of Final Research Achievements |
Mouse is the most commonly used animal for biomedical research. However, bile acid composition in mice is very different from that in humans. The most striking difference is a lack of chenodeoxycholic acid (CDCA) and the presence of muricholic acid (MCA) due to the activity of CDCA 6beta-hydroxylation in mice liver. In this study, we explored the enzyme that catalyzed 6beta-hydroxylation of CDCA and identified it as Cyp2c70. In addition, we made a mouse disrupted Cyp2c70 and confirmed that the mouse has CDCA instead of MCA.
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