| Project/Area Number |
15K15315
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 雅 北海道大学, 大学病院, 助教 (10374290)
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| Co-Investigator(Renkei-kenkyūsha) |
AKITA Hidetaka 千葉大学, 大学院薬学研究院, 教授 (80344472)
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| Research Collaborator |
KIMURA Hiroki 北海道大学, 大学院医学研究科, 学術研究員
SANTIWARANGKOOL Sarochin 北海道大学, 大学院薬学研究院, 大学院生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 核酸医薬 / 多機能性エンベロープナノ構造体 / siRNA / Nrf2 |
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| Outline of Final Research Achievements |
We tried to knockdown lung tissue specific Keap1 mRNA using GALA-MEND containing Keap1 siRNA, but it was difficult to achieve its knockdown with good efficiency and specificity to the lung tissue. Then, we tried to improve the function of GALA-MEND by PEGylation. As a result, PEGylated GALA-MEND showed better accumulation to lung endothelial cells. This improved GALA-MEND is thought to be promising for future research.
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