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The importance of polyamine activation in pulmonary hypertension

Research Project

Project/Area Number 15K15318
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

SAKAI Satoshi  筑波大学, 医学医療系, 講師 (30282362)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺高血圧症 / ポリアミン / メタボローム解析
Outline of Final Research Achievements

It occurs that marked increase of pulmonary arterial smooth muscle cells (PASMCs) in pulmonary arterial hypertension (PAH). By metabolomics analysis, the concentration of polyamine was significantly elevated in the lungs of hypoxia-induced PAH mice. By microarray analysis, the gene expression of S-adenosyl methionine decarboxylase in the lungs was markedly increased in PAH mice. Taken together, the augmentation of polyamine concentration would be due to the increased synthesis of decarboxylated S-adenosyl methionine, which was induced by the enhanced activity of S-adenosyl methionine decarboxylase. Because polyamine contributes to the proliferation of cancer cells, the increase of polyamine production in the lungs would also be involved in the enhanced proliferation of PASMCs in PAH, probably in a similar fashion.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Antagonists to endothelin receptor type B promone apoptosis in human pulmonary arterial smooth muscle cells.2016

    • Author(s)
      Sakai S, Maruyama H, Kimura T, Tajiri K, Honda J, Homma S, Aonuma K, Miyauchi T
    • Journal Title

      Life Sci

      Volume: In print Pages: 116-120

    • DOI

      10.1016/j.lfs.2016.03.044

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bosentan reverses the hypoxia-induced downregulation of the bone morphogenetic protein signaling in pulmonary artery smooth muscle cells2016

    • Author(s)
      Maruyama, H. Dewachter, C. Sakai, S. Belhaj, A. Rondelet, B. Remmelink, M. Vachiery, J. L. Naeije, R. Dewachter, L.
    • Journal Title

      Life Sci

      Volume: 159 Pages: 111-115

    • DOI

      10.1016/j.lfs.2016.05.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and Safety of a Novel Endothelin Receptor Antagonist, Macitentan, in Japanese Patients With Pulmonary Arterial Hypertension2016

    • Author(s)
      Tahara N, Dobashi H, Fukuda K, Funauchi M, Hatano M, Ikeda S, Joho S, Kihara Y, Kimura T, Kondo T, Matsushita M, Minamino T, Nakanishi N, Ozaki Y, Saji T, Sakai S, Tanabe N, Watanabe H, Yamada H, Yoshioka K, Sasayama S
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 6 Pages: 1478-1483

    • DOI

      10.1253/circj.CJ-15-1305

    • NAID

      130005153579

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis.2016

    • Author(s)
      Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
    • Journal Title

      Journal of Dermatological Science

      Volume: 83 Issue: 3 Pages: 226-233

    • DOI

      10.1016/j.jdermsci.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis2016

    • Author(s)
      Osamu Baba,Shogo Hasegawa,Hiroki Nagai,Fumihiko Uchida,Masanobu Yamatoji,Naomi I. Kanno,Kenji Yamagata,Satoshi Sakai,Toru Yanagawa,Hiroki Bukawa
    • Journal Title

      Journal of Oral Pathology & Medicine

      Volume: 45 Issue: 4 Pages: 248-255

    • DOI

      10.1111/jop.12351

    • NAID

      120007135548

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension2015

    • Author(s)
      Maruyama H, Dewachter C, Belhaj A, Rondelet B, Sakai S, Remmeling M, Vachiery J, Naeije R, Dewachter L
    • Journal Title

      J Heart Lung Transplantat

      Volume: 34 Issue: 3 Pages: 468-478

    • DOI

      10.1016/j.healun.2014.09.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] The decrease of S-wave amplitude in V5 lead of electrocardiography positively reflects effectual treatment in patients with pulmonary hypertension2017

    • Author(s)
      Otsu K, Sakai S, Kimura T, Miyauchi T, Homma S, Aonuma K
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト肺動脈血管平滑筋細胞に対するETB受容体遮断による影響2016

    • Author(s)
      酒井俊・丸山秀和・木村泰三・田尻和子・本田洵也・本間覚・青沼和隆・宮内卓
    • Organizer
      第20回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      東京コンベンションホール(東京都中央区)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hypoxia induces the down regulation of the BMP signaling in pulmonary artery smooth muscle cells through the endothelin system2016

    • Author(s)
      Maruyama H, Sakai S, Naeije R, Dewachter L, Aonuma K
    • Organizer
      Congress of the European-Society-of-Cardiology (ESC) 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lysol oxidase was increased by endothelin-1 and restored by PGI2 in pulmonary artery smooth muscle cells2016

    • Author(s)
      Maruyama H, Sakai S, Naeije R, Dewachter L, Aonuma K
    • Organizer
      Congress of the European-Society-of-Cardiology (ESC) 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulmonary hypertension is ameliorated by glucagon-like peptide-1 receptor agonist partly via eNOS activation2016

    • Author(s)
      Sakai S, Kimura T, Honda J, Tajiri K, Homma S, Aonuma K, Miyauchi T
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications f Nitric Oxide
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺高血圧進展におけるPin1 (Peptidyl isomerase1) の役割2015

    • Author(s)
      酒井 俊
    • Organizer
      第4回日本肺循環学会・第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      東京 東京ステーションコンファレンス
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of endothelin receptor antagonists on doxorubicin-induced apoptosis in vascular smooth muscle cells derived from human pulmonary artery2015

    • Author(s)
      Sakai S, et al.
    • Organizer
      14th International Conference on Endothelin
    • Place of Presentation
      Savannah, GA, USA
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bosentan reverses the hypoxia-induced downregulation of the bone morphogenetic protein signaling in pulmonary artery smooth muscle cells2015

    • Author(s)
      Maruyama H, Sakai S, et al
    • Organizer
      14th International Conference on Endothelin
    • Place of Presentation
      Savannah, GA, USA
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The glucagon-like peptide-1 receptor agonist improves hypoxia induced pulmonary hypertension in mice model2015

    • Author(s)
      Kimura T, Sakai S, et al.
    • Organizer
      Congress of the European-Society-of-Cardiology (ESC)
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-12-17  

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