Regulation of mitochondrial function for protection of acute kidney
| Project/Area Number |
15K15331
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
TERADA Yoshio 高知大学, 教育研究部医療学系臨床医学部門, 教授 (30251531)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 尿細管 / 腎不全 / オートファジー / マイトファジー / 急性腎障害 / ミトコンドリア |
|---|
| Outline of Final Research Achievements |
Acute kidney injury (AKI), often resulting from ischemic, toxic, and septic insults, is a common disorder with a high morbidity and mortality. The major morphologic changes in ischemic AKI include the effacement and loss of the proximal tubule brush border, patchy loss of tubular cells, areas of focal proximal tubular dilation, apoptosis, necrosis, and inflammation. We showed that HSPB1 expression increased during oxidative stress in AKI. Incremental HSPB1 expression increased autophagic flux and inhibited apoptosis in renal tubular cells. These results indicate that HSPB1 upregulation plays a role in the pathophysiology of AKI.
|
Report
(3 results)
Research Products
(11 results)
-
[Journal Article] Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version.2016
Author(s)
Usui J, Yamagata K, Imai E, Okuyama H, Kajiyama H, Kanamori H, Kaneko S, Kono E, Sakai Y, Sakai N, Sakamaki Y, Taniguchi Y, Nakai K, Nishiwaki H, Hirata S, Yamaya H, Tsuruoka S, Terada Y, Yokoyama H, Wada T, Narita I.
-
Journal Title
Clin Exp Nephrol.
Volume: 20
Issue: 6
Pages: 827-831
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Transition of adolescent and young adult patients with childhood-onset chronic disease from pediatric to adult renal services: a nationwide survey in Japan.2016
Author(s)
Hattori M, Iwano M, Sako M, Honda M, Okada H, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Maruyama S, Matsuo S.
-
Journal Title
Clin. Exp. Nephrol.
Volume: 印刷中
Issue: 6
Pages: 918-925
DOI
Related Report
-
-
-
-
-
-
-
-
-
