Regulation of mitochondrial function for protection of acute kidney

• Project/Area Number: 15K15331
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kochi University
• Principal Investigator: TERADA Yoshio 高知大学, 教育研究部医療学系臨床医学部門, 教授 (30251531)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 尿細管 / 腎不全 / オートファジー / マイトファジー / 急性腎障害 / ミトコンドリア

Outline of Final Research Achievements

Acute kidney injury (AKI), often resulting from ischemic, toxic, and septic insults, is a common disorder with a high morbidity and mortality. The major morphologic changes in ischemic AKI include the effacement and loss of the proximal tubule brush border, patchy loss of tubular cells, areas of focal proximal tubular dilation, apoptosis, necrosis, and inflammation. We showed that HSPB1 expression increased　during oxidative stress in AKI. Incremental　HSPB1 expression increased autophagic flux and inhibited apoptosis in renal tubular cells. These results indicate that HSPB1 upregulation plays a role in the pathophysiology of AKI.

Research Products

• [Journal Article] Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version. (2016)
  • Author(s): Usui J, Yamagata K, Imai E, Okuyama H, Kajiyama H, Kanamori H, Kaneko S, Kono E, Sakai Y, Sakai N, Sakamaki Y, Taniguchi Y, Nakai K, Nishiwaki H, Hirata S, Yamaya H, Tsuruoka S, Terada Y, Yokoyama H, Wada T, Narita I.
  • Journal Title: Clin Exp Nephrol. Volume: 20 Issue: 6 Pages: 827-831
  • DOI: 10.1007/s10157-016-1334-0
  • NAID: 120007135282
  • Peer Reviewed
• [Journal Article] Transition of adolescent and young adult patients with childhood-onset chronic disease from pediatric to adult renal services: a nationwide survey in Japan. (2016)
  • Author(s): Hattori M, Iwano M, Sako M, Honda M, Okada H, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Maruyama S, Matsuo S.
  • Journal Title: Clin. Exp. Nephrol. Volume: 印刷中 Issue: 6 Pages: 918-925
  • DOI: 10.1007/s10157-016-1231-6
• [Journal Article] 抗菌薬による腎障害．薬剤性腎障害 診療ガイドライン (2016)
  • Author(s): 谷口義典，寺田典生
  • Journal Title: 日本腎臓学会誌 Volume: 58 Pages: 31-34
• [Journal Article] 造影剤による腎障害 特集:薬剤性腎障害 (2016)
  • Author(s): 谷口義典，寺田典生
  • Journal Title: 日本腎臓学会誌 Volume: 58 Pages: 1079-1082
  • NAID: 40021008317
• [Journal Article] Small Heat Shock Protein Beta-1 (HSP1)Is Upregulated and Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury (2015)
  • Author(s): Matsumoto T，Urushido M，Ide H，Ishihara M，Hamada-ode K，Shimamura Y，Ogata K，Inoue K，Taniguchi Y，Taguchi T，Horino T，Fujimoto S，Terada Y
  • Journal Title: PLOS one Volume: 10 Issue: 5 Pages: e0126229-e0126229
  • DOI: 10.1371/journal.pone.0126229
  • Peer Reviewed / Open Access
• [Presentation] Interleukin(IL)-36 Axis Is Modulated in Mice Acute Kidney Injury Model and Human Urine. (2016)
  • Author(s): Hirofumi Nishikawa, Naoki Arima, Tatsuki Matsumoto,Yoshiko Shimamura, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino,Shimpei Fujimoto, Yoshio Terada
  • Organizer: ASN(American Society of Nephrology) Kidney Week 2016 Annual Meeting
  • Place of Presentation: McCormick Place（シカゴ、アメリカ合衆国）
  • Year and Date: 2016-11-15
• [Presentation] 急性腎障害(AKI) Up To Date (2016)
  • Author(s): 寺田 典生
  • Organizer: 第46回日本腎臓学会西部学術大会
  • Place of Presentation: シーガイヤコンベンションセンター（宮崎県宮崎市）
  • Year and Date: 2016-10-14
• [Presentation] Mitophagy and mitochondrial protection as a novel therapeutic strategy for AKI (2016)
  • Author(s): 寺田典生
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-06-17
• [Presentation] Role of Thioredoxin-Interacting Protein(TXNIP)in Mitochondrial Function of Renal Tubular Cells in Ischemia Reperfusion Injury AKI Model (2015)
  • Author(s): Maeda N，Matsumoto T, Terada Y
  • Organizer: The 48th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego, UAS
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Book] 薬剤性腎障害（DKI）診療Q&A －DKI 診療ガイドラインを実践するために－ (2017)
  • Author(s): 山縣邦弘、臼井丈一、成田一衛、寺田典生、平田純生
  • Total Pages: 321
  • Publisher: 診断と治療社
• [Book] 高齢者外来診察 スーパー総合医 (2015)
  • Author(s): 緒方巧二，松本竜季，大出佳寿，島村芳子，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Total Pages: 350
  • Publisher: 中山書店