| Project/Area Number |
15K15354
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Ogawa Yoshihiro 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70291424)
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| Research Collaborator |
TSUCHIYA Kyoichiro
SHIBA Kumiko
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | インスリン抵抗性 / リポカリン2 / 血管内皮細胞 / インスリンシグナル / 培養血管内皮細胞 |
|---|
| Outline of Final Research Achievements |
Insulin resistance and hyperglycemia activate transcription factor FoxO1 by dephosphorylation and deacetylation, respectively. We aimed to elucidate the pathophysiological roles of FoxO1 in diabetes-associated vascular injury, by identifying target genes of FoxO1 in endothelial cells and examining the regulatory mechanisms by FoxO1. Constitutive active FoxO1 mutant significantly induced Lcn2 (lipocalin-2/NGAL) gene in endothelial cells via Akt/NF-κB-dependent manner. It suggests that FoxO1 promotes type 2 diabetes-associated vascular dysfunction by induction of Lcn2 (lipocalin-2/NGAL) in endothelial cells.
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