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Regulation of digit development by transcription factors

Research Project

Project/Area Number 15K15387
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionShiga University of Medical Science (2016)
Tokyo Medical and Dental University (2015)

Principal Investigator

Mori Masaki  滋賀医科大学, 神経難病研究センター, 特任准教授 (10602625)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords形態形成 / 指芽発生 / パターニング / 転写因子 / 遺伝子ネットワーク / 発生学 / 発生 / 指芽 / ホメオチック遺伝子
Outline of Final Research Achievements

Limb bud patterning, outgrowth, and differentiation are precisely regulated in a spatio-temporal manner through integrated networks of transcription factors, signaling molecules, and downstream genes. However, the exact mechanisms that orchestrate morphogenesis of the limb remain to be elucidated. We focused our expression pattern analysis on a selection of transcription factor genes that exhibit spatially localized and temporally dynamic expression patterns with respect to the anterior-posterior axis in the E9.5-11.5 limb bud. In this project, we identified Hesr1/2 and Irx3 as the key genes that regulate the digit development.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Int'l Joint Research] National Institutes of Health/Salk Institute for Biological Studies(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Analysis of transcription factors expressed at the anterior mouse limb bud2017

    • Author(s)
      Yokoyama S, Furukawa S, Kitada S, Masaki Mori, Saito T, Kawakami K, Izpisua Belmonte JC, Kawakami Y, Ito Y, Sato T, Asahara H
    • Journal Title

      PLOS One

      Volume: na

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitochondrial Ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates alpha-Synuclein expression.2017

    • Author(s)
      Hongpeng Guan, HongKuan Yang, Mingchun Yang, Daijiro Yanagisawa, Jean-Pierre Bellier, Masaki Mori, Shogo Takahata, Takashi Nonaka, Shiguang Zhao, Ikuo Tooyama.
    • Journal Title

      Experimental Neurology

      Volume: 291 Pages: 51-61

    • DOI

      10.1016/j.expneurol.2017.02.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.2016

    • Author(s)
      Masashi Naito, Masaki Mori, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H.
    • Journal Title

      PLOS Genetics

      Volume: 12 Issue: 7 Pages: e1006167-e1006167

    • DOI

      10.1371/journal.pgen.1006167

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.2016

    • Author(s)
      Rho Nakamichi, Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 12503-12503

    • DOI

      10.1038/ncomms12503

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gtf2ird1-dependent Mohawk (Mkx) expression regulates mechanosensing properties of tendon2016

    • Author(s)
      Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 8 Pages: 1297-309

    • DOI

      10.1128/mcb.00950-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 小児の特性を活用した小児難病治療研究とマウスにおける若年性遺伝子群の同定2017

    • Author(s)
      森 雅樹
    • Organizer
      第120回日本小児科学会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] CRISPR/Cas9によるハンター症候群遺伝子変異を有するマウス系統樹立2017

    • Author(s)
      森 雅樹
    • Organizer
      第120回日本小児科学会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞競合の哺乳類成長での役割と染色体異常症への治療応用2017

    • Author(s)
      森 雅樹
    • Organizer
      第6回細胞競合コロキウム
    • Place of Presentation
      北海道
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] CRISPR/CAS9システムによるタグ配列導入による個体解析へのブレイクスルー2016

    • Author(s)
      古川聡一、森雅樹、浅原弘嗣
    • Organizer
      第5回細胞競合コロキウム
    • Place of Presentation
      北海道大学 (北海道札幌市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-02-16  

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