Transgenelation of behavioral abnormaliteis associated with DNA methylation signatures in sperm
| Project/Area Number |
15K15425
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
MATSUZAKI Hideo 福井大学, 子どものこころの発達研究センター, 教授 (00334970)
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| Co-Investigator(Kenkyū-buntansha) |
岩田 圭子 福井大学, 子どものこころの発達研究センター, 助教 (30415088)
小西 慶幸 福井大学, 学術研究院工学系部門, 准教授 (00382838)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 母体ストレス / マウス / 行動異常 / 遺伝子発現 / 精子 / エピジェネティックマーク |
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| Outline of Final Research Achievements |
In this study, we find that maternal stress influences behavior in subsequent generations. In addition, some gene expressions involved in the abnormal behaviors are changed in brains of subsequent generations. We also find that methylation status of these gene in sperm DNA is changed in subsequent generations. From these results, transgenelation of behavioral abnormalities associated with DNA methylation in sperm is suggested. In the future, detailed experiments of DNA methylation in sperm is needed.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Microglia-derived neuregulin expression in psychiatric disorders.2017
Author(s)
Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
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Journal Title
Brain Behav Immun.
Volume: 61
Pages: 375-385
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder.2017
Author(s)
Makinodan M, Iwata K, Ikawa D, Yamashita Y, Yamamuro K, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Yoshino H, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Matsuzaki H, Kishimoto T.
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Journal Title
Neurochem Int.
Volume: 104
Pages: 1-5
DOI
Related Report
Peer Reviewed
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[Journal Article] Fetal Environment and Glycosylation Status in Neonatal Cord Blood: A Comprehensive Mass Spectrometry-based Glycosylation Analysis.2016
Author(s)
Sato R, Tsuchiya KJ, Matsuzaki H, Takei N, Itoh H, Kanayama N, Suda T, Watanabe H, Ohashi T, Tanaka M, Nishimura S, Maekawa M, HBC study group
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Journal Title
Medicine (Baltimore).
Volume: 95(14)
Issue: 14
Pages: e3219-e3219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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