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Effect of repetitive and transcranial near infrared irradiation on inflammatory processes in the brain of rats.

Research Project

Project/Area Number 15K15426
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Takahashi Taro  浜松医科大学, 医学部, 特任助教 (30402358)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsLow level Laser therapy / BDNF / インターロイキン / Low level laser therapy / 神経栄養因子 / サイトカイン / Low level kaser therapy
Outline of Final Research Achievements

Immune activation processes including microglial activation in the brain have been implicated in the pathology of neurodevelopmental disorders such as schizophrenia and autism. Low-level laser therapy (LLLT) has been used in the treatment of inflammatory pathologies. In this study we examined possible therapeutic effects of LLLT on immune activations in the rat brain of offspring of dams exposed to poly I:C and GM-CSF. The immune activation in the rat brain wasn’t shown between poly I:C, GM-CSF and control group. However, the expression levels of BDNF were shown to increase while several cytokine (IL-1β, IL-6, IL-10) were shown to decrease after LLLT on the normal rat frontal cortex by using RT-PCR. Similarly the rat body temperature tended to elevated after LLLT. Especially activation of BDNF expression by LLLT was shown in rat pup brain and human neuroblastoma cell (SK-N-SH).The result suggests LLLT may affect brain function through modulation of expression BDNF and cytokine.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.2016

    • Author(s)
      Mundalil Vasu M, Anitha A, Takahashi T, Thanseem I, Iwata K, Asakawa T, Suzuki K.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 10 Pages: e0164425-e0164425

    • DOI

      10.1371/journal.pone.0164425

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of repetitive and transcranial near infrared irradiation on inflammatory processes in the brain of rats.2015

    • Author(s)
      高橋太郎
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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