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Development of the multidimensional assessment system for modern-type depression

Research Project

Project/Area Number 15K15431
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

Kato Takahiro  九州大学, 大学病院, 講師 (70546465)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsうつ病 / 気分障害 / ディスチミア親和型うつ / メランコリー親和型うつ / 信頼ゲーム / 血液バイオマーカー / 現代うつ / 新型うつ / 社会的ひきこもり / 脂質 / トリプトファン / 評価ツール / 現代型うつ / 社会的意思決定
Outline of Final Research Achievements

In Japan, a syndrome named “Modern-Type Depression (MTD)” has emerged in the past decade, seen predominately in young people, undergoing occasional depressive symptoms and evasive symptoms brought about when performance at work and school does not go well. Most cases of MTD are not as severe as major depressive disorder, and tend easily to be diagnosed as adjustment disorder. The purpose of this study is to develop the multidimensional assessment system for MTD.
We have developed a questionnaire to assess the traits of MTD (Kato et al. in preparation). In addition, we have revealed some psychosocial factors of MTD using our PC-based trust game. We have also revealed some possible blood biomarkers of MTD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (27 results)

All 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (16 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (2 results)

  • [Int'l Joint Research] オレゴン健康科学大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Hong Kong(中国(香港))

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Oregon Health & Science University(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Oregon Health & Science University(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study.2018

    • Author(s)
      Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
    • Journal Title

      Journal of Affective Disorders

      Volume: 231 Pages: 74-82

    • DOI

      10.1016/j.jad.2018.01.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.2018

    • Author(s)
      Hayakawa K, Kato TA*, Watabe M, Teo AR, Horikawa H, Shimokawa N, Sato-Kasai M, Kubo H, Ohgidani M, Sagata N, Toda H, Tateno M, Shinfuku N, Kishimoto J, Kanba S
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2884-2884

    • DOI

      10.1038/s41598-018-21260-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial.2018

    • Author(s)
      Nakagami Y, Kubo H, Katsuki R, Sakai T, Sugihara G, Naito C, Oda H, Hayakawa K, Suzuki Y, Fujisawa D, Hashimoto N, Kobara K, Cho T, Kuga H, Takao K, Kawahara Y, Matsumura Y, Murai T, Akashi K, Kanba S, Otsuka K, Kato TA
    • Journal Title

      Journal of Affective Disorders

      Volume: 225 Pages: 569-576

    • DOI

      10.1016/j.jad.2017.08.074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hikikomori: experience in Japan and international relevance.2018

    • Author(s)
      Kato TA*, Kanba S, Teo AR
    • Journal Title

      World Psychiatry

      Volume: 17(1) Issue: 1 Pages: 105-106

    • DOI

      10.1002/wps.20497

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 末梢血バイオマーカーを用いた精神医学評価システムの構築-現代のうつ病診断・評価における困難の打開に向けて.2018

    • Author(s)
      加藤隆弘
    • Journal Title

      精神医学

      Volume: 60(1) Pages: 51-62

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 青年期におけるアタッチメントの課題 (指定討論記録)2018

    • Author(s)
      加藤隆弘, 平野直己
    • Journal Title

      思春期青年期精神医学

      Volume: 27(2) Pages: 116-126

    • Related Report
      2017 Annual Research Report
  • [Journal Article] グローバリゼーションと社会的ひきこもり─ひきこもりは現代社会結合症候群か?─.2018

    • Author(s)
      加藤隆弘
    • Journal Title

      臨床精神医学

      Volume: 47(2) Pages: 137-145

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Modern-Type Depression as an "Adjustment" Disorder in Japan: The Intersection of Collectivistic Society Encountering an Individualistic Performance-Based System.2017

    • Author(s)
      Kato TA, Kanba S
    • Journal Title

      American Journal of Psychiatry

      Volume: 174(11) Issue: 11 Pages: 1051-1053

    • DOI

      10.1176/appi.ajp.2017.17010059

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?2017

    • Author(s)
      Wong PWC, Liu LL, Li TMH, Kato TA, Teo AR
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 30 Pages: 175-176

    • DOI

      10.1016/j.ajp.2017.10.026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 社会的ひきこもり・現代抑うつ症候群に対するモチベーション障害評価システムの構築2017

    • Author(s)
      加藤隆弘, 神庭重信
    • Journal Title

      最新精神医学

      Volume: 22(5) Pages: 383-389

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 「現代抑うつ症候群(新型うつ・現代うつ)」は閾値下うつ、あるいは、適応障害か?―精神医学的知見に鑑みて2017

    • Author(s)
      加藤隆弘, 桑野信貴, 神庭重信
    • Journal Title

      ストレス科学

      Volume: 32(1) Pages: 63-73

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 現代抑うつ症候群(現代うつ・新型うつ)に対する多軸的評価システムの構築:大学病院気分障害外来での取り組み紹介2016

    • Author(s)
      1.加藤隆弘, 早川宏平, 佐藤美那, 下川憲宏, 久保浩明, 香月亮子, 井上綾子, 倉原啓太, 堀川英喜, 田中耕司, 神庭重信
    • Journal Title

      精神科臨床サービス

      Volume: 16(2) Pages: 183-191

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 大学病院気分障害外来での「現代抑うつ症候群」への評価法・治療法の開発2016

    • Author(s)
      加藤隆弘, 神庭重信
    • Journal Title

      日本精神科病院協会雑誌

      Volume: 35(8) Pages: 741-746

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan.2016

    • Author(s)
      Kato TA*, Kanba S, Teo AR*
    • Journal Title

      American Journal of Psychiatry

      Volume: 173 Pages: 112-114

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Boundless syndromes in modern society – An interconnected world producing novel psychopathology in the 21st century.2016

    • Author(s)
      Kato TA*, Kanba S
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 70 Pages: 1-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The multidimensional anatomy of “modern type depression” in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5.2016

    • Author(s)
      Kato TA*, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 70

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Do human plasma metabolites predict severity of depression and suicidal ideation?. Symposium “Biomarker research for pathophysiology and treatment effect of affective disorders”2017

    • Author(s)
      Kato TA, Sanba S
    • Organizer
      5th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] うつ病を考える biology、psychology、psychopathologyから 脳内免疫細胞ミクログリアに焦点づけた気分障害研究:「死の欲動」の起源はミクログリアか?2017

    • Author(s)
      加藤隆弘, 神庭重信
    • Organizer
      第14回日本うつ病学会総会・第17回日本認知療法・認知行動療法学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クログリア仮説に鑑みた気分障害の血液バイオマーカー研究. シンポジウム「情動・脳高次機能解明の手続きとしてのメタボローム解析」2017

    • Author(s)
      加藤隆弘, 扇谷昌宏, 瀬戸山大樹, 康 東天, 神庭重信
    • Organizer
      第39回 日本生物学的精神医学会・第47回 日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミクログリア仮説に鑑みた気分障害の血液バイオマーカー研究. シンポジウム「うつ病における炎症・酸化ストレスの役割と創薬への発展性」2017

    • Author(s)
      加藤隆弘, 扇谷昌宏, 瀬戸山大樹, 康 東天, 神庭重信
    • Organizer
      第39回 日本生物学的精神医学会・第47回 日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hikikomori/Hidden Youth Definition.2017

    • Author(s)
      Kato TA
    • Organizer
      Hikikomori-Hidden Youth Syndrome Symposium in NUS Singapore
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] Loneliness and single person households: Issues of kodoku-shi and hikikomori in Japan. in Mental Health and Illness in the City2017

    • Author(s)
      Kato TA*, Shinfuku N, Sartorius N, Kanba S
    • Total Pages
      489
    • Publisher
      Springer Singapore
    • ISBN
      9789811023255
    • Related Report
      2017 Annual Research Report
  • [Book] 精神疾患とその治療 :『こころの科学』増刊『公認心理師入門―知識と技術』2017

    • Author(s)
      加藤隆弘
    • Total Pages
      175
    • Publisher
      日本評論社
    • ISBN
      9784535904460
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2022-02-22  

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