| Project/Area Number |
15K15448
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
KURACHI Masashi 群馬大学, 大学院医学系研究科, 助教 (20271546)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血管内皮細胞 / 医学放射線生物学 / 神経科学 / 放射線 / 血管新生 |
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| Outline of Final Research Achievements |
In the normal mouse brain tissue after X-ray irradiation, acute increase of vascular permeability was induced. The amount of vascular endothelial cell growth factor VEGF in the brain decreased. In the X-ray irradiated cerebral cortex, the activated microglia remarkably increased, and the expression of the tight junction protein, claudin-5, which is expressed specifically in vascular endothelial cells, was decreased. X-ray irradiation on Flk1-GFP/Flt1-tdsRed BAC transgenic mice increased the proportion of GFP-positive vascular endothelial cells in brain microvessels. The cerebrovascular images in Tg mouse brain reflecting the expression levels of Flt1 and Flk1 in vascular endothelial cells were obtained using two-photon microscopy.
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