| Project/Area Number |
15K15495
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Taura Kojiro 京都大学, 医学研究科, 講師 (80378629)
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| Co-Investigator(Kenkyū-buntansha) |
上本 伸二 京都大学, 医学研究科, 教授 (40252449)
波多野 悦朗 京都大学, 医学研究科, 客員研究員 (80359801)
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| Research Collaborator |
NISHIO Takahiro 京都大学, 大学院医学研究科, 大学院生
Yamamoto Gen 京都大学, 大学院医学研究科, 大学院生
TANABE Kazutaka 京都大学, 大学院医学研究科, 大学院生
OKUDA Yukihiro 京都大学, 大学院医学研究科, 大学院生
IKENO Yoshinobu 京都大学, 大学院医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | NASH / 迷走神経 / クッパー細胞 / ニコチン性アセチルコリン受容体α7 |
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| Outline of Final Research Achievements |
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by steatosis with progressive inflammation. Kupffer cells, which are liver-resident macrophages, play a central role in promoting hepatic inflammation by innate immune responses in NASH. The efferent vagus nerve signaling is known to have an anti-inflammatory effect on immune cells via the α7 nicotinic acetylcholine receptor (α7nAChR) pathway. This study demonstrated that the hepatic vagus nerve plays a key role in regulating the inflammatory response in Kupffer cells via the α7nAChR pathway and eventually contributed to the suppression of NASH progression, by using mouse experimental model of NASH.
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