Imaging of degenerative vascular tissue structure of congenital heart disease by high-resolution phase contrast CT imaging using synchrotron radiation.

• Project/Area Number: 15K15505
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Niigata University
• Principal Investigator: Takahashi Masashi 新潟大学, 医歯学総合研究科, 特任教授 (30303150)
• Co-Investigator(Kenkyū-buntansha): 白石 修一 新潟大学, 医歯学総合病院, その他 (00422600)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 放射光 / 動脈管 / 分子構造解析 / 放射光位相差X線CT法 / SPring8 / 先天性心疾患 / 血管退縮性疾患

Outline of Final Research Achievements

Although mortality of congenital heart disease with degenerative vascular lesion is very high, a mechanism of vascular degeneration has not been known. X-ray Phase-contrast tomography is an imaging modality for biological soft tissue that does not destroy or alter the properties of specimen. X-ray Phase-contrast tomography has been applied to structural analysis of degenerative vascular lesion. This modality has cleared up a mechanism of degenerative vascular lesion without destruction of vessels. The X-ray Phase-contrast tomography is thought to be very useful to clear up lots of unknown mechanisms of congenital heart disease.