Function of (pro)renin receptor in human iPS cell.

• Project/Area Number: 15K15511
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Saitama Medical University
• Principal Investigator: Senbonmatsu Takaaki 埼玉医科大学, 医学部, 教授 (70216563)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: （プロ）レニン受容体 / iPS細胞 / 中胚葉誘導 / WNTシグナル / ヒトiPS細胞 / プロレニン受容体

Outline of Final Research Achievements

(Pro)renin receptor is one molecule of Renin angiotensin system (RAS), and non proteolically evokes renin activity of prorenin, while there are several articles that show RAS independent functions of (P)RR. We found that (P)RR was highly expressed in human iPS cell. Full-length (P)RR was mainly localized in the nucleus and might play an important role in differentiation induction of human iPS cell.