| Project/Area Number |
15K15514
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
渡邉 龍秋 東北大学, 加齢医学研究所, 非常勤講師 (70636034)
星川 康 藤田保健衛生大学, 医学部, 教授 (90333814)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
DEZAWA Mari 東北大学, 医学部, 教授 (50272323)
|
|---|
| Research Collaborator |
YABUKI Hiroshi 東北大学, 医学系研究科, 大学院生
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 肺移植 / 虚血・再灌流傷害 / 間葉系幹細胞 / Muse細胞 |
|---|
| Outline of Final Research Achievements |
Lung ischemia-reperfusion injury is a signify complication after lung transplantation. We examined the effect of Multi-lineage differentiating Stress Enduring cell (Muse cells) on ameliorating lung ischemia-reperfusion injury in a rat model. Human Muse cells (Muse group), human mesenchymal stem cells (MSC group) or PBS (Vehicle group) were infused into the left pulmonary artery after 2-hour ischemia and subsequent reperfusion. On days 3 and 5 after reperfusion, the Muse group showed the most favorable arterial blood gas, left lung compliance and histological scores for IR injury among 3 groups. The present study indicated that administration of Muse cells ameliorate lung ischemia-reperfusion injury in a rat model.
|
