Maternal behavior impairments in ASIC1a knockout female mice

• Project/Area Number: 15K15554
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University
• Principal Investigator: Wakabayashi Kenjiro 名古屋市立大学, 大学院医学研究科, 助教 (20418867)
• Co-Investigator(Kenkyū-buntansha): 和田 郁雄 名古屋市立大学, 大学院医学研究科, 教授 (70182970) ; 佐久間 英輔 名古屋市立大学, 大学院医学研究科, 講師 (90295585) ; 村上 里奈 名古屋市立大学, 大学院医学研究科, 助教 (10535818) ; 青山 公紀 名古屋市立大学, 大学院医学研究科, 助教 (10597818)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 育児障害 / 酸感受性イオンチャンネル / ドーパミン / トランスポーター / ミクログリア / SGK1 / 脳内炎症 / イオンチャンネル / マウス / 脳

Outline of Final Research Achievements

The acid-sensing ion channel (ASIC) family is a major branch of the mechanosensory degenerin/epithelial Na+ channel superfamily. Here, we report that acid-sensing ion channels (ASICs) type 1a knockout (KO) female mice exhibit the impairment in maternal behavior. The ASIC 1a KO female mice also show the downregulation of the dopamine transporter (DAT). While the function of these interactions is not well understood, it might be possible that the interactions between coexisting plural channels and transporters play some crucial roles to maintain the synaptic action. In this paper, we propose that the ASIC 1a KO female mice express the impairment in maternal behavior from the downregulation of the DAT.

Research Products

• [Journal Article] Serum- and glucocorticoid-inducible kinases in microglia. (2016)
  • Author(s): Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 478 Issue: 1 Pages: 53-59
  • DOI: 10.1016/j.bbrc.2016.07.094
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. (2016)
  • Author(s): Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.
  • Journal Title: Mol Psychiatry Volume: 21 Issue: 11 Pages: 1-11
  • DOI: 10.1038/mp.2015.220
  • Peer Reviewed / Open Access
• [Presentation] Potential implication of SGK1-demedent activity change in BV-2 microglial cells (2017)
  • Author(s): 浅井勇人、井上浩一、佐久間英輔、植木孝俊
  • Organizer: Neuroscience 2017 Washington, DC
  • Int'l Joint Research
• [Presentation] ミクログリアにおけるリン酸化酵素 SGK1 の機能解析 (2017)
  • Author(s): 井上浩一、浅井勇人、佐久間英輔、植木孝俊
  • Organizer: 第77回中部支部学術集会
• [Presentation] リン酸化酵素SGKによるミクログリア活性の調節 (2016)
  • Author(s): 井上浩一、佐久間英輔、森本浩之、和田郁雄、植木孝俊
  • Organizer: 第121回日本解剖学会総会全国学術集会
  • Place of Presentation: ビッグパレットふくしま（福島県郡山市）
  • Year and Date: 2016-03-28
• [Presentation] ASIC1aノックアウトマウスの育児障害 (2016)
  • Author(s): 若林健二郎,佐久間英輔,植木孝俊,井上浩一,大塚隆信,和田郁雄,水谷潤,植木美乃, 村上里奈,青山公紀,井上浩一,河命守, 白井康裕,森本浩之,小出益徳,浅井友詞
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）