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Role of orexinergic neurons in sepsis

Research Project

Project/Area Number 15K15561
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionHirosaki University

Principal Investigator

Hirota Kazuyoshi  弘前大学, 医学研究科, 教授 (20238413)

Co-Investigator(Kenkyū-buntansha) 櫛方 哲也  弘前大学, 医学研究科, 准教授 (80250603)
橋場 英二  弘前大学, 医学部附属病院, 准教授 (10374844)
丹羽 英智  弘前大学, 医学部附属病院, 講師 (20374845)
斎藤 淳一  弘前大学, 医学部附属病院, 助教 (90647413)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords敗血症 / オレキシン / ラット / メラニン凝集ホルモン
Outline of Final Research Achievements

Orexin(OX) neurons which are degenerated by sepsis contributes to cardiovascular control. Thus, we have determined whether OX system contributes to the survival from sepsis with lipopolysaccharide(LPS: 10mg/kg) in OX/ataxin-3 transgenic(group-TG) and Sprague-Dawley(group-SD) rats, and determined relationship between severity of illness and plasma OXA in sepsis and non-sepsis ICU patients. Survival analysis was done for 3 days after LPS or saline (group-C) given. In group-SD 61.5% rats survived while only 21.4% in group-TG(p<0.05). LPS significantly reduced pons OXA(pg/mg tissue) from 4.10+/-1.21 to 2.92+/-0.38pg/mg tissue (p<0.05), and OXA content in group-TG was substantially lower than that in group-C and SD in all brain regions. In clinical study, plasma OXA did not significantly change during ICU stay and did not correlate to APATCH2 score. Therefore, although animal data suggest contribution of OX neurons for survival in sepsis, clinical data did not support this hypothesis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pilot Study of Changes in Presepsin Concentrations Compared With Changes in Procalcitonin and C-Reactive Protein Concentrations After Cardiovascular Surgery.2017

    • Author(s)
      Saito J, Hashiba E, Mikami A, Kudo T, Niwa H, Hirota K.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: 17 Issue: 4 Pages: 1262-1267

    • DOI

      10.1053/j.jvca.2017.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sepsis and the orexin system.2016

    • Author(s)
      Hirota K
    • Journal Title

      Journal of Anesthesia

      Volume: 30 Issue: 6 Pages: 919-922

    • DOI

      10.1007/s00540-016-2246-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Orexinergic tone affects survival in sepsis in rats.2017

    • Author(s)
      Hirota K, Takekawa D, Kushikata T, Kudo M.
    • Organizer
      BJA Research Forum Winter Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 敗血症患者における血中オレキシン濃度の変化の検討.2017

    • Author(s)
      赤石真啓、橋場英二、天内絵理香、太田大地、櫛方哲也、廣田和美.
    • Organizer
      日本麻酔科学会第64回学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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