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The role of endothelial microparticles in ARDS

Research Project

Project/Area Number 15K15562
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionTohoku University

Principal Investigator

Saito Kouji  東北大学, 大学病院, 准教授 (10359515)

Co-Investigator(Renkei-kenkyūsha) Takei Yusuke  東北大学, 大学病院, 助教 (80822890)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsARDS / 内皮微小粒子 / 血管内皮傷害 / 敗血症 / microparticles / バイオマーカー / 内皮傷害
Outline of Final Research Achievements

We investigated the role of the angiotensin+ endothelial microparticles (ACE+EMPs) as a pulmonary endothelial injury. More ACE+EMPs were released from Human pulmonary microvascular endothelial cells than other endothelial cells and increased by inflammatory stimuli. Circulating ACE+EMPs were significantly higher in septic patients with ARDS than patients without ARDS. Furthermore, ACE+EMPs increased significantly in mouse lung injury model and correlate with the severity of pulmonary microvascular permeability. Circulating ACE+ EMPs could therefore be a useful marker for evaluating pulmonary endothelial injury during ARDS.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Circulating ACE+ EMPs are a potential marker for evaluating pulmonary endothelial injury during ARDS2018

    • Author(s)
      Yusuke Takei
    • Organizer
      The International Conference American Thoracic Society 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ACE陽性EMPに着目した新規ARDSバイオマーカーの開発2017

    • Author(s)
      武井 祐介
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] Endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討2017

    • Author(s)
      武井 祐介
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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