The role of endothelial microparticles in ARDS

Research Project

Project/Area Number	15K15562
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Tohoku University
Principal Investigator	Saito Kouji 東北大学, 大学病院, 准教授 (10359515)
Co-Investigator(Renkei-kenkyūsha)	Takei Yusuke 東北大学, 大学病院, 助教 (80822890)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	ARDS / 内皮微小粒子 / 血管内皮傷害 / 敗血症 / microparticles / バイオマーカー / 内皮傷害
Outline of Final Research Achievements	We investigated the role of the angiotensin+ endothelial microparticles (ACE+EMPs) as a pulmonary endothelial injury. More ACE+EMPs were released from Human pulmonary microvascular endothelial cells than other endothelial cells and increased by inflammatory stimuli. Circulating ACE+EMPs were significantly higher in septic patients with ARDS than patients without ARDS. Furthermore, ACE+EMPs increased significantly in mouse lung injury model and correlate with the severity of pulmonary microvascular permeability. Circulating ACE+ EMPs could therefore be a useful marker for evaluating pulmonary endothelial injury during ARDS.