| Project/Area Number |
15K15571
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 静脈麻酔薬 / 下垂体前葉 / プロオピオメラノコルチン / アストロサイト / エリスロポイエチン / 低酸素誘導因子 / Wnt/βカテニン経路 / 麻酔薬 / グリア細胞 / 低酸素 / Wnt蛋白 / Wnt淡白 |
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| Outline of Final Research Achievements |
We analyzed the effects of intravenous anesthetics on the depolarization-induced proopiomelanocortin expression, mediated by the activation of voltage-dependent Ca2+ channel and Ca2+ influx, in anterior pituitary cells. It was suggested that intravenous anesthetics, including propofol, thiopental, midazolam and diazepam, suppressed the depolarization-induced proopiomelanocortin expression, possibly by suppression of the voltage-dependent Ca2+ channel and by reduction of the affinity to cyclic AMP of protein kinase A.
It is known that hypoxia-inducible factor (HIF) is involved in the hypoxia-induced erythropoietin expression in astrocytes. We analyzed the effect of midazolam on the hypoxia-induced erythropoietin expression in astrocytes. It was suggested that midazolam suppressed the hypoxia-induced erythropoietin expression in astrocytes by inhibition of translocation of HIF-1alpha into the nucleus.
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