Elucidation of molecular mechanisms of the anesthetic action regarding fear memory constitution
Project/Area Number |
15K15575
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
|
Research Institution | Aichi Medical University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 麻酔薬 / 記憶 / 思春期 / 脳 / セボフルラン |
Outline of Final Research Achievements |
The current study was designed to evaluate whether the inhalation of volatile anesthetic sevoflurane (2.5% for 3 hours) enhances the long-term fear memory learning ability in combination with the F-actin constitution as well as rac-1 protein expression in the hippocampus in four-weeks-old young adult mice. Sevoflurane exposure to young adult mice accelerated the long-term fear memory with the increased F-actin constitution and rac-1 protein expression in the hippocampus. These results indicate that sevoflurane may enhance fear memory consolidation in young adults of humans.
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Report
(4 results)
Research Products
(3 results)