Elucidation of molecular mechanisms of the anesthetic action regarding fear memory constitution

Research Project

Project/Area Number	15K15575
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Aichi Medical University
Principal Investigator	Kinoshita Hiroyuki 愛知医科大学, 公私立大学の部局等, 客員研究員 (70291490)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	麻酔薬 / 記憶 / 思春期 / 脳 / セボフルラン
Outline of Final Research Achievements	The current study was designed to evaluate whether the inhalation of volatile anesthetic sevoflurane (2.5% for 3 hours) enhances the long-term fear memory learning ability in combination with the F-actin constitution as well as rac-1 protein expression in the hippocampus in four-weeks-old young adult mice. Sevoflurane exposure to young adult mice accelerated the long-term fear memory with the increased F-actin constitution and rac-1 protein expression in the hippocampus. These results indicate that sevoflurane may enhance fear memory consolidation in young adults of humans.

Report

(4 results)