Research and development of serological diagnosis of gynecological cancer.

• Project/Area Number: 15K15602
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Sugihara Kazuhiro 浜松医科大学, 医学部, 准教授 (00265878)
• Co-Investigator(Kenkyū-buntansha): 村上 浩雄 浜松医科大学, 医学部附属病院, 助教 (10432212) ; 柴田 俊章 浜松医科大学, 医学部, 助教 (50529568)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: バイオマーカー / 血清マーカー / 婦人科学

Outline of Final Research Achievements

The molecule which specifically expressed for malignant tumors of the field of gynecology and obstetrics was screened. We carried out close inspection in mind in possibilities of the clinical application continuously. In 2018, we identified the molecule which specifically expressed for gynecologic cancer. The molecule expressed with various tissues of ovarian cancer. After the approval of the Ethical Review Board, we are investigating whether it can be the biomarker.

Research Products

• [Presentation] Enhancement of human sperm motility by novel recombinant endo-β-galactosidases. (2017)
  • Author(s): Shibata T, and Sugihara K.
  • Organizer: 64th annual scientific meeting (SRI 2017).
  • Place of Presentation: Orland USA.
  • Year and Date: 2017-03-15
  • Int'l Joint Research
• [Presentation] Development of future medical treatment. Pro-apoptotic peptides as potential treatment for endometriosis. (2016)
  • Author(s): Shibata T. and Sugihara K.
  • Organizer: 5th Asian Conference on Endometriosis.
  • Place of Presentation: Osaka Japan.
  • Year and Date: 2016-09-22
  • Int'l Joint Research / Invited
• [Presentation] 子宮内膜症に対するペプチド治療薬の探索 (2016)
  • Author(s): 杉原一廣
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-06-30
• [Presentation] ペプチド創薬 (2016)
  • Author(s): 杉原一廣
  • Organizer: 藤田保健衛生大学セミナー
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 産婦人科生殖腫瘍分野のトランスレーショナルリサーチ (2016)
  • Author(s): 杉原一廣
  • Organizer: 社会医療法人蘇西厚生会学術講演会
  • Place of Presentation: 岐阜
  • Invited
• [Presentation] 腫瘍血管新生、VEGF、ベバシズマブ (2016)
  • Author(s): 杉原一廣
  • Organizer: 第２回婦人科腫瘍勉強会
  • Place of Presentation: 静岡
  • Invited