roles of fibroblats in endometriosis for tumor transformation
| Project/Area Number |
15K15611
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Juntendo University |
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Principal Investigator |
KITADE Mari 順天堂大学, 医学部, 教授 (20266026)
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| Co-Investigator(Kenkyū-buntansha) |
折茂 彰 順天堂大学, 医学(系)研究科(研究院), 准教授 (70275866)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 子宮内膜症 / チョコレート嚢腫 / 疾患マウスモデル / 線維芽細胞 / 癌化 / 子宮内膜症マウスモデル / 個別化癌転移モデル / 治療抵抗性 / 腫瘍内線維化 / 腹腔内転移 / 癌微小環境 / 子宮内膜症モデルマウス / HLA 1 ABC抗体 / Ki-67抗体 / ジェノグラフトモデル |
|---|
| Outline of Final Research Achievements |
Endometriosis is a progressive disease that causes infertility and malignant transformation. In this study, we developed a mouse model for endometriosis by implantation of the affected tissues surgically dissected from totally 8 patients into immunodeficient mice. Sarcoma-like tumors were emerged in two out of eight patients.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.2018
Author(s)
Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.
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Journal Title
Nat Med
Volume: 24(4)
Issue: 4
Pages: 463-473
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.2018
Author(s)
Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
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Journal Title
Oncogene.
Volume: 37
Issue: 9
Pages: 1205-1219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.2016
Author(s)
Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM.
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Journal Title
Oncotarget, Oncotarget.
Volume: 7
Pages: 76920-76933
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.2016
Author(s)
Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.
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Journal Title
Oncogene
Volume: 235
Pages: 5585-5596
Related Report
Peer Reviewed / Acknowledgement Compliant
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