| Project/Area Number |
15K15660
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Chiba University |
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Principal Investigator |
ODA Shigeto 千葉大学, 大学院医学研究院, 教授 (90204205)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | ICU / 貧血 / エリスロポエチン / 患者重症度 / 採血量 / ICU患者 / 輸血 / エリスロポエチン製剤 / 長期転帰 |
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| Outline of Final Research Achievements |
Anemia or red blood cell(RBC)transfusion is harmful and associated with poor outcome in critically ill patients.Although several factors inducing anemia in critically ill patients have been reported,it is unclear which factor significantly contributes to anemia in critically ill.Thus,we investigated factors contributing to anemia in 110 critically ill patients(50 patients who received RBC transfusion within 28 days and 60 non-transfused patients).There was no difference in the serum levels of Fe,vitamin B12 and the erythropoietin,the factors related to erythropoiesis.However,the inflammatory markers are significantly higher in the transfused patients.In addition, blood collection volume was significantly higher in transfused patients than non-transfused patients.As a result,greater inflammatory response and greater volume of blood sampling were identified as the significant contributing factors to anemia in critically ill patients.
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