| Project/Area Number |
15K15690
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森 士朗 東北大学, 大学病院, 講師 (80230069)
飯久保 正弘 東北大学, 歯学研究科, 講師 (80302157)
小嶋 郁穂 東北大学, 歯学研究科, 助教 (80447169)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ITO Koichi 東北大学, 情報科学研究科, 助教 (70400299)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | リンパ節転移 / マウスモデル / 超音波 / ナノバブル / マイクロCT / リンパ節転移モデル / ニッチ形成 / 画像診断 / 造影CT / 造影超音波画像 / 血管密度 / 超早期診断 / ナノ・マイクロバブル / マイクロＣＴ |
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| Outline of Final Research Achievements |
To develop an image analysis system to detect niche formation leading to lymph node (LN) metastasis formation, changes in vascular architecture in the process of LN metastasis formation were analyzed using contrast micro CT imaging and contrast high frequency ultrasound imaging. In the present study, tumor cells were inoculated into the subiliac LN (SiLN) of LN-swollen mouse, MXH10/Mo/lpr, and then metastasis formation process in the proper axillary LN located downstream of SiLN in mouse lymph network was analyzed. The results showed that, in the early stage of LN metastasis, blood vessel density in the LN prior to LN size change was increased. However, angiogenesis in the LN at the early stage of LN metastasis could not be confirmed.
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