The effect of stealth-typed midazolam-encapsulating nano drug carrier on bioavailability of midazolam following oral administration

Research Project

Project/Area Number	15K15739
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Okayama University
Principal Investigator	Miyawaki Takuya 岡山大学, 医歯薬学総合研究科, 教授 (00219825)
Research Collaborator	MORI Megumi TANIMURA Hiroshi
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	歯学 / 薬理学 / 麻酔薬 / リポソーム
Outline of Final Research Achievements	The purpose of the present study was to find the appropriate condition to produce miniaturized midazolam-encapsulating liposome as a stealth-typed drug carrier and to evaluate the effect of the miniaturized liposome-encapsulated midazolam on the bioavailability of midazolam and investigate its mechanism. As a result we found the appropriate condition to produce miniaturized midazolam-encapsulating liposome. The miniaturized midazolam-encapsulating liposomes produced in that condition increased the bioavailability of midazolam on oral administration, and the mechanism was suggested to be due to the increase of absorption of miniaturized midazolam-encapsulating liposomes in the intestine.

Report

(3 results)