The effect of stealth-typed midazolam-encapsulating nano drug carrier on bioavailability of midazolam following oral administration
Project/Area Number |
15K15739
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Okayama University |
Principal Investigator |
Miyawaki Takuya 岡山大学, 医歯薬学総合研究科, 教授 (00219825)
|
Research Collaborator |
MORI Megumi
TANIMURA Hiroshi
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 歯学 / 薬理学 / 麻酔薬 / リポソーム |
Outline of Final Research Achievements |
The purpose of the present study was to find the appropriate condition to produce miniaturized midazolam-encapsulating liposome as a stealth-typed drug carrier and to evaluate the effect of the miniaturized liposome-encapsulated midazolam on the bioavailability of midazolam and investigate its mechanism. As a result we found the appropriate condition to produce miniaturized midazolam-encapsulating liposome. The miniaturized midazolam-encapsulating liposomes produced in that condition increased the bioavailability of midazolam on oral administration, and the mechanism was suggested to be due to the increase of absorption of miniaturized midazolam-encapsulating liposomes in the intestine.
|
Report
(3 results)
Research Products
(3 results)