| Project/Area Number |
15K15762
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
OKA KYOKO 福岡歯科大学, 口腔歯学部, 准教授 (60452778)
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| Co-Investigator(Kenkyū-buntansha) |
敦賀 英知 弘前大学, 保健学研究科, 教授 (30295901)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯の外傷 / 歯根発生 / 歯根膜再生 / ヘルトヴィッヒ上皮鞘 / TGF-β / Periostin / Fibrillin / Periosatin / ヘルトビッヒ上皮鞘 / 歯の再植 |
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| Outline of Final Research Achievements |
Avulsion is the severest type of dental trauma. The prognosis depends on the success of periodontal ligament regeneration after re-plantation. In re-plantation of an avulsed tooth, it has been thought that the viability of periodontal ligament cells on the root surface is a critical factor for PDL regeneration. We examined about mechanism of root development and regeneration of periodontal ligament tissue. For the clinical success of tooth re-plantation, we established ''mouse tooth re-plantation model'', and investigate the effect of artificial material for periodontal ligament tissue regeneration.
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