Charange to regenerate the periodontal ligament using mouse tooth re-plantation model
| Project/Area Number |
15K15762
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
OKA KYOKO 福岡歯科大学, 口腔歯学部, 准教授 (60452778)
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| Co-Investigator(Kenkyū-buntansha) |
敦賀 英知 弘前大学, 保健学研究科, 教授 (30295901)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯の外傷 / 歯根発生 / 歯根膜再生 / ヘルトヴィッヒ上皮鞘 / TGF-β / Periostin / Fibrillin / Periosatin / ヘルトビッヒ上皮鞘 / 歯の再植 |
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| Outline of Final Research Achievements |
Avulsion is the severest type of dental trauma. The prognosis depends on the success of periodontal ligament regeneration after re-plantation. In re-plantation of an avulsed tooth, it has been thought that the viability of periodontal ligament cells on the root surface is a critical factor for PDL regeneration. We examined about mechanism of root development and regeneration of periodontal ligament tissue. For the clinical success of tooth re-plantation, we established ''mouse tooth re-plantation model'', and investigate the effect of artificial material for periodontal ligament tissue regeneration.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] <b>Hertwig’s epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by </b><b>TGF-β </b>2017
Author(s)
Itaya, S., Oka, K., Ogata, K., Tamura, S., Kira-Tatsuoka, M., Fujiwara, N., Otsu, K., Tsuruga, E., Ozaki, M., and Harada, H.
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Journal Title
Biomedical Research
Volume: 38
Issue: 1
Pages: 61-69
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access
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[Journal Article] Choice of feeders is important when first establishing iPSCs derived from primarily cultured human deciduous tooth dental pulp cells.2015
Author(s)
Saitoh I, Inada E, Iwase Y, Noguchi H, Murakami T, Soda M, Kubota N, Hasegawa H, Akasaka E, Matsumoto Y, Oka K, Yamasaki Y, Hayasaki H, Sato M
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Journal Title
Cell Medicine
Volume: 8
Issue: 1-2
Pages: 9-23
DOI
Related Report
Peer Reviewed / Open Access
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