| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We performed this study with a periodontitis-associated microbe, Filfactor alocis, as a target. First, we tried to isolate a F. alocis-specific bacteriophage from culture supernatant acquired from F. alocis continuous culture. This experiment still continues today.
Next, we performed an amino acids profiling of F. alocis culture supernatant, to know the influence of F. alocis on oral microbiome dysbiosis by secreting metabolites into the environment. It was revealed that 10 L-amino acids （Asn, Ser, Gly, Ala, Pro, Val, Ile, Leu, Phe, Lys）and 4 D-amino acids were secreted by F. alocis. This finding will provide clues about dysbiosis in oral microbiome.
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