Research for relationship between oral microboiome and head and neck and digestive organ cancers
| Project/Area Number |
15K15774
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹内 研時 九州大学, 歯学研究院, 助教 (10712680)
竹下 徹 九州大学, 歯学研究院, 准教授 (50546471)
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| Co-Investigator(Renkei-kenkyūsha) |
TOU Yasushi 独立行政法人国立病院機構, 副病院長 (20217459)
MORITA Masaru 独立行政法人国立病院機構, 消化器外科, 科長 (30294937)
MASUDA Muneyuki 独立行政法人国立病院機構, 頭頸部外科, 科長 (90284504)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯学 / 細菌 / 口腔マイクロバイオーム / 頭頸部がん / 消化器がん |
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| Outline of Final Research Achievements |
The purpose of this study is the characterization of the oral microbiome related to head and neck, digestive organ cancer. Saliva was collected from the patients who had a diagnosis of head and neck cancer or a digestive organ cancer in National Hospital Organization Kyushu Cancer Center. Salivary microbiome was analyzed with the next-generation sequencer. The results were compared with those of the salivary microbiome of dwelling population at Hisayama town to aim the identification of a special microbe or the unique constitution pattern to cancer patients. As a result, the salivary microbiome constitution peculiar to the patients of head and neck, digestive organ cancer was not recognized, but the constituent ratio of some bacterial species was significantly different between a cancer patients and non-cancer dwelling population.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study.2016
Author(s)
Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.
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Journal Title
Science Reorts
Volume: 6
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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