| Project/Area Number |
15K16132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
ISHIZUKA Mayumi 北海道大学, 大学院獣医学研究科・毒性学教室, 教授 (50332474)
IKENAKA Yoshinori 北海道大学, 大学院獣医学研究科・毒性学教室, 准教授 (40543509)
NAKAYAMA Shouta 北海道大学, 大学院獣医学研究科・毒性学教室, 助教 (90647629)
TAKIGUCHI Mitsuyoshi 北海道大学, 大学院獣医学研究科・内科学教室, 教授 (70261336)
NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター化学汚染・毒性解析部門, 准教授 (30512686)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ネコ / 甲状腺ホルモン / PCBs / PBDEs / 代謝能 / リスク評価 / 生体内動態 / シトクロムP450（CYPs） / オミクス解析 / 生化学マーカー / 甲状腺機能 / 脱臭素化 / in vivo / 甲状腺機能亢進症 / 有機ハロゲン化合物 / 肝ミクロソーム |
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| Outline of Final Research Achievements |
To clarify the in vivo kinetics (absorption, distribution, metabolism, and excretion) of organohalogen compounds in cats, PCBs short-term administration test and long-term administration test of BDE 209 were carried out. Also, I have evaluated the influence on thyroid function and risk assessment by chemical and toxicological analysis. As a result, exposure to PCBs and BDE 209 not only affected thyroid function but also increased oxidative stress, disturbance of production of NADPH, disturbance of lipid metabolism function and immune function were expected.
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