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Elucidation for metabolic capacities of organologen compounds and assessment of thyroid function

Research Project

Project/Area Number 15K16132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionHokkaido University

Principal Investigator

MIZUKAWA HAZUKI  北海道大学, 獣医学研究院, 助教 (60612661)

Research Collaborator ISHIZUKA Mayumi  北海道大学, 大学院獣医学研究科・毒性学教室, 教授 (50332474)
IKENAKA Yoshinori  北海道大学, 大学院獣医学研究科・毒性学教室, 准教授 (40543509)
NAKAYAMA Shouta  北海道大学, 大学院獣医学研究科・毒性学教室, 助教 (90647629)
TAKIGUCHI Mitsuyoshi  北海道大学, 大学院獣医学研究科・内科学教室, 教授 (70261336)
NOMIYAMA Kei  愛媛大学, 沿岸環境科学研究センター化学汚染・毒性解析部門, 准教授 (30512686)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsネコ / 甲状腺ホルモン / PCBs / PBDEs / 代謝能 / リスク評価 / 生体内動態 / シトクロムP450(CYPs) / オミクス解析 / 生化学マーカー / 甲状腺機能 / 脱臭素化 / in vivo / 甲状腺機能亢進症 / 有機ハロゲン化合物 / 肝ミクロソーム
Outline of Final Research Achievements

To clarify the in vivo kinetics (absorption, distribution, metabolism, and excretion) of organohalogen compounds in cats, PCBs short-term administration test and long-term administration test of BDE 209 were carried out. Also, I have evaluated the influence on thyroid function and risk assessment by chemical and toxicological analysis. As a result, exposure to PCBs and BDE 209 not only affected thyroid function but also increased oxidative stress, disturbance of production of NADPH, disturbance of lipid metabolism function and immune function were expected.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (83 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 13 results,  Acknowledgement Compliant: 5 results) Presentation (60 results) (of which Int'l Joint Research: 21 results,  Invited: 4 results) Remarks (5 results)

  • [Int'l Joint Research] Kasetsart University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Mongolian University of Life Sciences(モンゴル)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] モンゴル国立農業大学(モンゴル)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Kasetsart University(タイ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Changes in renal peritubular capillaries in canine and feline chronic kidney disease2018

    • Author(s)
      Nakamura R, Yabuki A, Ichii O, Mizukawa H, Yokoyama N, Yamato O
    • Journal Title

      Journal of Comparative Pathology

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species2018

    • Author(s)
      Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M.
    • Journal Title

      CBP

      Volume: 印刷中

    • NAID

      120006769940

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Species Differences in Xenobiotic Metabolism in Non-experimental Animals2017

    • Author(s)
      水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 3 Pages: 257-263

    • DOI

      10.1248/yakushi.16-00230-2

    • NAID

      130005396880

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2017-03-01
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores2017

    • Author(s)
      Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
    • Journal Title

      Toxicological Sciences

      Volume: 158 Issue: 1 Pages: 90-100

    • DOI

      10.1093/toxsci/kfx072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anthropogenic and naturally produced brominated phenols in pet blood and pet food in Japan2017

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Miyuki Yamamoto, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 19 Pages: 11354-11362

    • DOI

      10.1021/acs.est.7b01009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Species- and tissue-specific profiles of polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in cats and dogs2017

    • Author(s)
      Kei Nomiyama , Kohki Takaguchi, Hazuki Mizukawa, Yasuko Nagano, Tomoko Oshihoi, Susumu Nakatsu, Tatsuya Kunisue, Shinsuke Tanabe
    • Journal Title

      Environmental Science & Technology

      Volume: 51 Issue: 10 Pages: 5811-5819

    • DOI

      10.1021/acs.est.7b01262

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam2016

    • Author(s)
      Nakayama SMM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M
    • Journal Title

      Journal of Veterinary Pharmacology and Therapeutics

      Volume: in press Issue: 5 Pages: 478-87

    • DOI

      10.1111/jvp.12303

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities.2016

    • Author(s)
      Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M.
    • Journal Title

      Comp Biochem Physiol C Pharmacol Toxicol.

      Volume: 190 Pages: 38-47

    • DOI

      10.1016/j.cbpc.2016.08.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances?2016

    • Author(s)
      Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
    • Journal Title

      Environmental Science & Technology

      Volume: 50 Issue: 1 Pages: 444-452

    • DOI

      10.1021/acs.est.5b04216

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In vitro and in silico analyses for predicting hepatic cytochrome p450-dependent metabolic potencies of polychlorinated biphenyls in the Baikal seal2015

    • Author(s)
      Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun-Young Kim, Shinsuke Tanab, Hisato Iwata
    • Journal Title

      Environmental Science and Technology

      Volume: 49 Issue: 24 Pages: 14588-14596

    • DOI

      10.1021/acs.est.5b03890

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] UGT Xenobiotic metabolizing activity and genetic evolution in Pinniped species2015

    • Author(s)
      Kakehi M, Ikenaka Y, Nakayama M.M.S, Kawai Y.K, Watanabe K.P, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M
    • Journal Title

      Toxicological Sciences

      Volume: 147 Issue: 2 Pages: 360-369

    • DOI

      10.1093/toxsci/kfv144

    • NAID

      120005817898

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization and tissue distribution of conjugated metabolites of pyrene in the rat2015

    • Author(s)
      Saengtienchai A, Ikenaka Y, DarwishWS, Nakayama M.M.S, Mizukawa H, Ishizuka M
    • Journal Title

      The Journal of Veterinary Medical Science

      Volume: 77 Pages: 1261-1267

    • NAID

      130005107595

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P4502015

    • Author(s)
      Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S
    • Journal Title

      Environ Res

      Volume: 138 Pages: 255-263

    • DOI

      10.1016/j.envres.2015.02.012

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Characteristics of CYP450 expression in cat exposed PCBs: Estimating the potential toxicity2018

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 有機ハロゲン化合物曝露によるネコの生化学マーカーの変化および甲状腺機能に及ぼす影響評価2018

    • Author(s)
      水川葉月、Kraisiri Khidkhan、高口倖暉、横山望、市居修、滝口満喜、笹岡一慶、池中良徳、中山翔太、野見山桂、田辺信介、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ネコのin vivo BDE209長期曝露試験による体内動態の解明および甲状腺ホルモンへの影響評価2018

    • Author(s)
      田中啓介、野見山桂、水川葉月、高口倖暉、田上瑠美、横山望、市居修、滝口満喜、笹岡一慶、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清中メタボローム解析によるペットネコ(Felis catus)の有機ハロゲン化合物毒性影響評価2018

    • Author(s)
      野見山桂、江口哲史、水川葉月、山本恭央、西川博之、滝口満喜、中山翔太、池中良徳、石塚真由美、田辺信介
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] タイ王国におけるペットネコ血清およびペットフード中有機ハロゲン化合物と類縁化合物の汚染実態2018

    • Author(s)
      島崎真琴、野見山桂、水川葉月、Aksorn Saengtienchai、Araya Ngamchirttakul、Disdanai Pencharee、石塚真由美、池中良徳、中山翔太、国末達也、田辺信介
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 野生哺乳類における硫酸転移酵素の動物種差解明2018

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、三谷曜子、田辺信介 、野見山桂、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリ塩化ビフェニル曝露によるイヌ・ネコの甲状腺ホルモン恒常性への影響2018

    • Author(s)
      髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Trace Elemental Profiles of Serum and Cerebrospinal Fluid in Dogs with Idiopathic Epilepsy2018

    • Author(s)
      Kazuyoshi Sasaoka, Hiroshi Ohta, Hazuki Mizukawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi
    • Organizer
      2018 ACVIM Forum (American College of Veterinary Internal Medicine)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 犬の特発性てんかんにおける血中及び脳脊髄液中微量元素濃度の検討2018

    • Author(s)
      笹岡一慶、大田寛、水川葉月、中山翔太、佐々木東、森下啓太郎、池中良徳、石塚真由美、滝口満喜
    • Organizer
      第14回 日本獣医内科学アカデミー学術大会(JCVIM 2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 陸棲哺乳類の血中に残留する臭素化フェノール類の曝露源解明と感受性の種差2017

    • Author(s)
      水川葉月
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イエネコのin vivo長期曝露試験:デカブロモジフェニルエーテル(BDE209)は甲状腺機能亢進症を引き起こすのか?2017

    • Author(s)
      水川葉月、野見山桂、池中良徳、中山翔太、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、笹岡一慶、市居修、Kraisiri Khidkhan、高居名菜、滝口満喜、田辺信介、石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)暴露によるネコ甲状腺機能への影響評価~甲状腺ホルモンの脱ヨード化と代謝能の解析~2017

    • Author(s)
      水川葉月、高居名菜、横山望、市居修、滝口満喜、野見山桂、高口倖暉、西川博之、池中良徳、中山翔太、Tsend-ayush Sainnoxoi、田辺信介、石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価2017

    • Author(s)
      野見山桂、西川 博之、水川葉月、髙口倖暉、Tsend-ayush Sainnoxoi、横山 望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PCBs曝露がイヌ・ネコの甲状腺ホルモン恒常性へ及ぼす影響2017

    • Author(s)
      髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、芳之内結加、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イエネコのin vivo長期曝露試験:デカブロモジフェニルエーテル(BDE209)の生体内変化2017

    • Author(s)
      田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高次栄養段階生物への化学物質の感受性の種差2017

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      2017年度第31回環境ホルモン学会講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inveatigation of biochemical changes in cat exposed organohalogen compounds2017

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ塩化ビフェニル(PCBs)のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価2017

    • Author(s)
      水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis2017

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short-term or long-term in vivo exposure to organohalogen compounds in cats: Elucidate the metabolic capacities and effects on thyroid function2017

    • Author(s)
      Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kei Nomiyama, Misaki Maehara, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Kraisiri Khidkhan, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Khoki Takaguchi, Hiroki Nishikawa, Nana Takai, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      9th International Toxicology Symposium in Nigeria
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Organohalogen Compounds on Serum Biochemical Profiles in Cats2017

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      The 5th Sapporo Summer Seminar for One Health (SaSSOH)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cats and dogs as sentinels for mercury exposure2017

    • Author(s)
      Rafael Barros, Hugo Vilhena, Hugo Brancal, Egidia Guerreiro, Hazuki Mizukawa, Ana C.A. Sousa, M. Ramiro Pastorinho
    • Organizer
      The 5th Sapporo Summer Seminar for One Health (SaSSOH)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Indoor exposure for polychlorinated biphenyls (PCBs) in domestic cats ~Pilot study of Mongolian pet cat~2017

    • Author(s)
      Hazuki Mizukawa, Yoshinori Ikenaka, Tsend-Ayush Sainnoxoi, Kohki Takaguchi, Kei Nomiyama, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      The 2nd Symposium on the Improvement of Diagnosis and Prevention of some Diseases Caused by Environmental Change
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats2017

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      SETAC North America 38th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ塩化ビフェニル(PCBs)がネコの甲状腺機能に及ぼす影響2017

    • Author(s)
      水川葉月、高居名菜、野見山桂、高口倖暉、横山望、市居修、滝口満喜、池中良徳、中山翔太、石塚真由美
    • Organizer
      環境ホルモン学会第20回研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 代謝酵素の動物種差2017

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      日本薬学会第137年会シンポジウム
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Invited
  • [Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats2016

    • Author(s)
      Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      The 7th SETAC World Congress/37th SETAC North America Annual Meeting
    • Place of Presentation
      Rosen Shingle Creek, Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis2016

    • Author(s)
      Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe
    • Organizer
      The 7th SETAC World Congress/37th SETAC North America Annual Meeting
    • Place of Presentation
      Rosen Shingle Creek, Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cross omics analysis for PCBs toxicity in the dog brain -Effect of mitochondria function-2016

    • Author(s)
      Kohki Takaguchi, Kei Nomiyama, Lauan Maria Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe
    • Organizer
      The 7th SETAC World Congress/37th SETAC North America Annual Meeting
    • Place of Presentation
      Rosen Shingle Creek, Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats2016

    • Author(s)
      Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Toxicological assessment of PCBs and OH-PCBs in the brain of dogs using metabolomics approach2016

    • Author(s)
      Kei Nomiyama, Kohki Takaguchi, Akifumi Eguchi, Hazuki, Mizukawa, Jean, Yoo, Saya, Tamura, Tomoko, Oshihoi, Hisato, Iwata, Tatsuya, Kunisue, Shinsuke Tanabe
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Disruption of mitochondrial functions by PCB exposure in the dog brain: Toxicological assessment using cross omics2016

    • Author(s)
      Kohki Takaguchi, Kei Nomiyama, Akifumi Eguchi, Lauan Maria Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 野生げっ歯類の殺鼠剤の抵抗性メカニズムと非対象動物に対する毒性メカニズム2016

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      日本哺乳類学会2016年度大会「企画シンポジウム:野生動物が関わる問題にどのように対応するか?~基礎研究を応用した解決への取り組み~」
    • Place of Presentation
      筑波大学、つくば市、茨城県
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~2016

    • Author(s)
      Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      The 4th Sapporo Summer Seminar for One Health (SaSSOH)
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] UGT2Bサブファミリーに着目した食肉目におけるグルクロン酸抱合能の動物種差解明2016

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
    • Organizer
      平成28年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      静岡県立大学薬学部、静岡市、静岡県
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 野生動物及び実験動物におけるグルクロン酸抱合酵素の動物種差解明2016

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部、藤沢市、神奈川県
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 犬と猫の慢性腎臓病における尿細管周囲毛細血管の変化2016

    • Author(s)
      中村麗菜、矢吹 映、市居 修、水川葉月、横山 望、大和 修
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部、藤沢市、神奈川県
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs2016

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] クロスオミックスによるイヌ脳の PCBs 毒性評価(Cross omics analysis for PCBs toxicity in the dog brain)2016

    • Author(s)
      髙口倖暉、野見山桂、Lauan Maria Claret、Yoo Jean、水川葉月、岩田久人、国末達也、田辺信介
    • Organizer
      日本プロテオーム学会2016年大会
    • Place of Presentation
      北里大学、東京都港区
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] ハリネズミは化学物質高感受性種? African hedgehog (Atalerix albiventris)で観察された低薬物代謝能2016

    • Author(s)
      アクソルン サエンティエンチャイ、池中 良徳、ネスタ サム、ウスマ ジャムナーク、水川 葉月、中山 翔太、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、名古屋、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川 葉月、前原 美咲、横山 望、市居 修、滝口 満喜、野見山 桂、西川 博之、池中 良徳、中山 翔太、高口 倖暉、田辺 信介、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、名古屋、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Research-status Report
  • [Presentation] UGTの動物種差2016

    • Author(s)
      石塚 真由美、中山 翔太、水川 葉月、池中 良徳
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、名古屋、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
    • Organizer
      第43回日本毒性学会
    • Place of Presentation
      ウィングあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2015 Research-status Report
  • [Presentation] ネコにおけるポリ塩化ビフェニル(PCBs)の異物代謝機構解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Presentation] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価2016

    • Author(s)
      野見山 桂、山本 恭央、水川 葉月、江口 哲史、滝口 満喜、中山 翔太、池中 良徳、石塚 真由美、国末 達也、田辺 信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Presentation] メタボローム解析を用いたPCBsによるイエネコの毒性影響評価2016

    • Author(s)
      西川博之、野見山桂、水川葉月、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Presentation] クロスオミックスによるイヌ脳へのPCBs毒性評価:ミトコンドリア機能へ及ぼす影響解析2016

    • Author(s)
      高口 倖暉、野見山 桂、Lauan Maria Claret、草木 桃子、Yoo Jean、水川 葉月、岩田 久人、国末 達也、田辺 信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Presentation] メタボロミクスアプローチを用いたイヌ脳へのOH-PCBs毒性機序の解明2016

    • Author(s)
      野見山 桂、高口 倖暉、江口 哲史、水川 葉月、Yoo Jean、田村 沙弥、忍穂井 智子、岩田 久人、国末 達也、田辺 信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 非実験動物における化学物質代謝能の特徴と種差2016

    • Author(s)
      池中良徳、筧麻友、水川葉月、中山翔太、石塚真由美
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] BIOTRANSFORMATION POTENCIES OF POLYCHROLINATED BIPHENYLS IN CATS2016

    • Author(s)
      Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      INTERNATIONAL SYMPOSIUM ON ENVIRONMENTAL CHEMISTRY AND TOXICOLOGY – TO ACCELERATE A GLOBAL NETWORK OF ENVIRONMENTAL RESEARCHERS
    • Place of Presentation
      Matsuyama, Ehime, Japan
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 化学物質の汚染環境に生きる野生動物の適応戦略2016

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      一般社団法人日本環境化学会25周年記念講演会:「環境化学の今、そして未来へ-環境化学からの提言-」
    • Place of Presentation
      発明会館地下ホール、東京都港区
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Metabolism and biotransformation of organohalogen compounds in the liver microsomes of cats and dogs2015

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Nozomu, Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama,Misaki Maehara, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      SETAC North America 36th Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Omics approach of proteomic and metabolomic analysis for PCBs toxicity in the dog brain2015

    • Author(s)
      Kohki Takaguchi, Kei Nomiyama, Lauan M. Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe.
    • Organizer
      SETAC North America 36th Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats: effects on thyroid hormones homeostasis2015

    • Author(s)
      Yasuo Yamamoto, Kei Nomiyama, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Tatsuya Kunisue, Shinsuke Tanabe
    • Organizer
      SETAC North America 36th Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase II xenobiotic metabolizm in carnivora -UGT activity and genomestructure in Pinniped species-2015

    • Author(s)
      Yoshinori Ikenaka, Mayu Kakehi, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      7th SETAC Africa Conference
    • Place of Presentation
      Langebaan, South Africa
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 第 II 相抱合反応の種差:食肉目におけるグルクロン酸抱合酵素の進化と遺伝子構造2015

    • Author(s)
      池中良徳 、筧 麻友、中山翔太、川合佑典、渡邊研右、水川葉月、野見山 桂、田辺信介、石塚真由美
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] メタボローム解析によるイヌ脳中PCBs, OH-PCBsの毒性影響評価2015

    • Author(s)
      野見山 桂、江口哲史、水川葉月、Yoo Jean、高口倖暉、山本泰央、忍穂井 智子、岩田久人、国末達也、田辺信介
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)を曝露したイヌの脳プロテオーム解析による毒性影響評価2015

    • Author(s)
      高口倖暉、野見山桂、Lauan Maria Claret 、草木桃子、Yoo Jean、水川葉月、岩田久人、国末達也、田辺信介
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)曝露によるイヌ異物代謝酵素シトクロムP450発現への影響評価2015

    • Author(s)
      田村沙弥、劉 珍、水川葉月、阿草哲郎、平野将司、野見山 桂、田辺信介、金 恩英、岩田久人
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ペットネコにおける有機ハロゲン化合物および水酸化代謝物の汚染実態と甲状腺ホルモン恒常性への影響2015

    • Author(s)
      山本恭央、野見山桂、水川葉月、滝口満喜、石塚真由美、国末達也、田辺信介
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Remarks] 北海道大学大学院獣医学研究院毒性学教室HP

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 海道大学大学院獣医学研究院毒性学教室Facebook

    • URL

      https://www.facebook.com/tox.vetmed.hokudai/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院毒性学教室Facebook

    • URL

      https://www.facebook.com/tox.vetmed.hokudai/

    • Related Report
      2016 Research-status Report
  • [Remarks] 北海道大学大学院獣医学研究科毒性学教室HP

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2015 Research-status Report
  • [Remarks] 北海道大学大学院獣医学研究科毒性学教室Facebook

    • URL

      https://www.facebook.com/tox.vetmed.hokudai/

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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