Elucidation for metabolic capacities of organologen compounds and assessment of thyroid function

• Project/Area Number: 15K16132
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hokkaido University
• Principal Investigator: MIZUKAWA HAZUKI 北海道大学, 獣医学研究院, 助教 (60612661)
• Research Collaborator: ISHIZUKA Mayumi 北海道大学, 大学院獣医学研究科・毒性学教室, 教授 (50332474) ; IKENAKA Yoshinori 北海道大学, 大学院獣医学研究科・毒性学教室, 准教授 (40543509) ; NAKAYAMA Shouta 北海道大学, 大学院獣医学研究科・毒性学教室, 助教 (90647629) ; TAKIGUCHI Mitsuyoshi 北海道大学, 大学院獣医学研究科・内科学教室, 教授 (70261336) ; NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター化学汚染・毒性解析部門, 准教授 (30512686)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ネコ / 甲状腺ホルモン / PCBs / PBDEs / 代謝能 / リスク評価 / 生体内動態 / シトクロムP450（CYPs） / オミクス解析 / 生化学マーカー / 甲状腺機能 / 脱臭素化 / in vivo / 甲状腺機能亢進症 / 有機ハロゲン化合物 / 肝ミクロソーム

Outline of Final Research Achievements

To clarify the in vivo kinetics (absorption, distribution, metabolism, and excretion) of organohalogen compounds in cats, PCBs short-term administration test and long-term administration test of BDE 209 were carried out. Also, I have evaluated the influence on thyroid function and risk assessment by chemical and toxicological analysis. As a result, exposure to PCBs and BDE 209 not only affected thyroid function but also increased oxidative stress, disturbance of production of NADPH, disturbance of lipid metabolism function and immune function were expected.

Research Products

• [Int'l Joint Research] Kasetsart University(タイ)
• [Int'l Joint Research] Mongolian University of Life Sciences(モンゴル)
• [Int'l Joint Research] カセサート大学(タイ)
• [Int'l Joint Research] モンゴル国立農業大学(モンゴル)
• [Int'l Joint Research] Kasetsart University(タイ)
• [Journal Article] Characterization of Species Differences in Xenobiotic Metabolism in Non-experimental Animals (2018)
  • Author(s): 水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美
  • Journal Title: YAKUGAKU ZASSHI Volume: 137 Issue: 3 Pages: 257-263
  • DOI: 10.1248/yakushi.16-00230-2
  • NAID: 130005396880
  • ISSN: 0031-6903
  • Year and Date: 2018-08-30
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in renal peritubular capillaries in canine and feline chronic kidney disease (2018)
  • Author(s): Nakamura R, Yabuki A, Ichii O, Mizukawa H, Yokoyama N, Yamato O
  • Journal Title: Journal of Comparative Pathology Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species (2018)
  • Author(s): Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M.
  • Journal Title: CBP Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Collagen-enriched serpiginous skin lesion in a cat resembling linear form of localized scleroderma in humans (2018)
  • Author(s): T Kanno, R Ishihara, S Hatama, Y oue, H Edamatsu, Y Konnno, S Tachibana, K Murakami
  • Journal Title: J Vet Med Sci. Volume: 76 Pages: 1077-1079
  • NAID: 130006743746
  • Peer Reviewed / Open Access
• [Journal Article] UDP-glucuronosyltransferase (UGT) 2B subfamily interspecies differences in carnivores. (2017)
  • Author(s): Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
  • Journal Title: Toxicological Sciences Volume: 158 Pages: 90-100
  • DOI: 10.1093/toxsci/kfx072
  • Peer Reviewed / Open Access
• [Journal Article] Anthropogenic and Naturally Produced Brominated Phenols in Pet Blood and Pet Food in Japan. (2017)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Miyuki Yamamoto, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe
  • Journal Title: Environ. Sci. Technol. Volume: 51 Pages: 11354-11362
  • DOI: 10.1021/acs.est.7b01009
  • Peer Reviewed / Open Access
• [Journal Article] Species- and Tissue-Specific Profiles of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Derivatives in Cats and Dogs (2017)
  • Author(s): Kei Nomiyama , Kohki Takaguchi, Hazuki Mizukawa, Yasuko Nagano, Tomoko Oshihoi, Susumu Nakatsu, Tatsuya Kunisue, Shinsuke Tanabe
  • Journal Title: Environmental Science & Technology Volume: 51 Pages: 5811-5819
  • DOI: 10.1021/acs.est.7b01262
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam. (2016)
  • Author(s): Nakayama SMM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M
  • Journal Title: Journal of Veterinary Pharmacology and Therapeutics. Volume: in press Pages: 478-487
  • DOI: 10.1111/jvp.12303
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities. (2016)
  • Author(s): Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M.
  • Journal Title: Comp Biochem Physiol C Pharmacol Toxicol. Volume: 190 Pages: 38-47
  • DOI: 10.1016/j.cbpc.2016.08.005
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Organohalogen compounds in pet dog and cat: do pets biotransform natural brominated products in food to harmful hydroxylated substances? (2016)
  • Author(s): Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
  • Journal Title: Environ. Sci. Technol. Volume: 50 Pages: 444-452
  • DOI: 10.1021/acs.est.5b04216
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In vitro and in silico analyses for predicting hepatic cytochrome P450-dependent metabolic potencies of polychlorinated bipenyls in the baikal seal. (2015)
  • Author(s): Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun-Young Kim, Shinsuke Tanab, Hisato Iwata
  • Journal Title: Environ. Sci. Technol. Volume: 49 Pages: 14588-14596
  • DOI: 10.1021/acs.est.5b03890
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Uridine diphosphate-glucuronosyltransferase (UGT) xenobiotic metabolizing activity and genetic evolution in Pinniped species (2015)
  • Author(s): Kakehi M, Ikenaka Y, Nakayama M.M.S, Kawai Y.K, Watanabe K.P, Mizukawa H, Nomiyama K, Tanabe S, Ishizuka M
  • Journal Title: Tox Sci Volume: 147 Pages: 360-369
  • DOI: 10.1093/toxsci/kfv144
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: association with hepatic cytochrome P450 (2015)
  • Author(s): Mizukawa H, Nomiyama K, Kunisue T, Watanabe MX, Subramanian A, Iwata H, Ishizuka M, Tanabe S
  • Journal Title: Environmental Reserch Volume: 138 Pages: 255-263
  • DOI: 10.1016/j.envres.2015.02.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Characteristics of CYP450 expression in cat exposed PCBs: Estimating the potential toxicity (2018)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: 第27回環境化学討論会
• [Presentation] 有機ハロゲン化合物曝露によるネコの生化学マーカーの変化および甲状腺機能に及ぼす影響評価 (2018)
  • Author(s): 水川葉月、Kraisiri Khidkhan、高口倖暉、横山望、市居修、滝口満喜、笹岡一慶、池中良徳、中山翔太、野見山桂、田辺信介、石塚真由美
  • Organizer: 第27回環境化学討論会
• [Presentation] ネコのin vivo BDE209長期曝露試験による体内動態の解明および甲状腺ホルモンへの影響評価 (2018)
  • Author(s): 田中啓介、野見山桂、水川葉月、高口倖暉、田上瑠美、横山望、市居修、滝口満喜、笹岡一慶、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
  • Organizer: 第27回環境化学討論会
• [Presentation] 血清中メタボローム解析によるペットネコ（Felis catus）の有機ハロゲン化合物毒性影響評価 (2018)
  • Author(s): 野見山桂、江口哲史、水川葉月、山本恭央、西川博之、滝口満喜、中山翔太、池中良徳、石塚真由美、田辺信介
  • Organizer: 第27回環境化学討論会
• [Presentation] タイ王国におけるペットネコ血清およびペットフード中有機ハロゲン化合物と類縁化合物の汚染実態 (2018)
  • Author(s): 島崎真琴、野見山桂、水川葉月、Aksorn Saengtienchai、Araya Ngamchirttakul、Disdanai Pencharee、石塚真由美、池中良徳、中山翔太、国末達也、田辺信介
  • Organizer: 第27回環境化学討論会
• [Presentation] 野生哺乳類における硫酸転移酵素の動物種差解明 (2018)
  • Author(s): 近藤誉充、池中良徳、中山翔太、水川葉月、三谷曜子、田辺信介 、野見山桂、石塚真由美
  • Organizer: 第27回環境化学討論会
• [Presentation] ポリ塩化ビフェニル曝露によるイヌ・ネコの甲状腺ホルモン恒常性への影響 (2018)
  • Author(s): 髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介
  • Organizer: 第45回日本毒性学会学術年会
• [Presentation] Trace Elemental Profiles of Serum and Cerebrospinal Fluid in Dogs with Idiopathic Epilepsy (2018)
  • Author(s): Kazuyoshi Sasaoka, Hiroshi Ohta, Hazuki Mizukawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi
  • Organizer: 2018 ACVIM Forum (American College of Veterinary Internal Medicine)
  • Int'l Joint Research
• [Presentation] 犬の特発性てんかんにおける血中及び脳脊髄液中微量元素濃度の検討 (2018)
  • Author(s): 笹岡一慶、大田寛、水川葉月、中山翔太、佐々木東、森下啓太郎、池中良徳、石塚真由美、滝口満喜
  • Organizer: 第14回 日本獣医内科学アカデミー学術大会（JCVIM 2018）
• [Presentation] 陸棲哺乳類の血中に残留する臭素化フェノール類の曝露源解明と感受性の種差 (2017)
  • Author(s): 水川葉月
  • Organizer: 第44回日本毒性学会学術年会
  • Invited
• [Presentation] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル（BDE209）は甲状腺機能亢進症を引き起こすのか？ (2017)
  • Author(s): 水川葉月、野見山桂、池中良徳、中山翔太、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、笹岡一慶、市居修、Kraisiri Khidkhan、高居名菜、滝口満喜、田辺信介、石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] ポリ塩化ビフェニル（PCBs）暴露によるネコ甲状腺機能への影響評価～甲状腺ホルモンの脱ヨード化と代謝能の解析～ (2017)
  • Author(s): 水川葉月、高居名菜、横山望、市居修、滝口満喜、野見山桂、高口倖暉、西川博之、池中良徳、中山翔太、Tsend-ayush Sainnoxoi、田辺信介、石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価 (2017)
  • Author(s): 野見山桂、西川 博之、水川葉月、髙口倖暉、Tsend-ayush Sainnoxoi、横山 望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] PCBs曝露がイヌ・ネコの甲状腺ホルモン恒常性へ及ぼす影響 (2017)
  • Author(s): 髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、芳之内結加、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル(BDE209)の生体内変化 (2017)
  • Author(s): 田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] 高次栄養段階生物への化学物質の感受性の種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 2017年度第31回環境ホルモン学会講演会
• [Presentation] Inveatigation of biochemical changes in cat exposed organohalogen compounds (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
  • Int'l Joint Research
• [Presentation] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価 (2017)
  • Author(s): 水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis (2017)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: 37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
  • Int'l Joint Research
• [Presentation] Short-term or long-term in vivo exposure to organohalogen compounds in cats: Elucidate the metabolic capacities and effects on thyroid function (2017)
  • Author(s): Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kei Nomiyama, Misaki Maehara, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Kraisiri Khidkhan, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Khoki Takaguchi, Hiroki Nishikawa, Nana Takai, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research
• [Presentation] Effects of Organohalogen Compounds on Serum Biochemical Profiles in Cats (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Cats and dogs as sentinels for mercury exposure (2017)
  • Author(s): Rafael Barros, Hugo Vilhena, Hugo Brancal, Egidia Guerreiro, Hazuki Mizukawa, Ana C.A. Sousa, M. Ramiro Pastorinho
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Indoor exposure for polychlorinated biphenyls (PCBs) in domestic cats ~Pilot study of Mongolian pet cat~ (2017)
  • Author(s): Hazuki Mizukawa, Yoshinori Ikenaka, Tsend-Ayush Sainnoxoi, Kohki Takaguchi, Kei Nomiyama, Shouta M.M. Nakayama, Mayumi Ishizuka
  • Organizer: The 2nd Symposium on the Improvement of Diagnosis and Prevention of some Diseases Caused by Environmental Change
  • Int'l Joint Research
• [Presentation] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] ポリ塩化ビフェニル（PCBs）がネコの甲状腺機能に及ぼす影響 (2017)
  • Author(s): 水川葉月、高居名菜、野見山桂、高口倖暉、横山望、市居修、滝口満喜、池中良徳、中山翔太、石塚真由美
  • Organizer: 環境ホルモン学会第20回研究発表会
• [Presentation] 代謝酵素の動物種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 日本薬学会第137年会シンポジウム
  • Invited
• [Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats (2016)
  • Author(s): Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: The 7th SETAC World Congress/37th SETAC North America Annual Meeting
  • Place of Presentation: Rosen Shingle Creek, Orlando, FL, USA
  • Year and Date: 2016-11-06
  • Int'l Joint Research
• [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis (2016)
  • Author(s): Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe
  • Organizer: The 7th SETAC World Congress/37th SETAC North America Annual Meeting
  • Place of Presentation: Rosen Shingle Creek, Orlando, FL, USA
  • Year and Date: 2016-11-06
  • Int'l Joint Research
• [Presentation] Cross omics analysis for PCBs toxicity in the dog brain -Effect of mitochondria function- (2016)
  • Author(s): Kohki Takaguchi, Kei Nomiyama, Lauan Maria Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: The 7th SETAC World Congress/37th SETAC North America Annual Meeting
  • Place of Presentation: Rosen Shingle Creek, Orlando, FL, USA
  • Year and Date: 2016-11-06
  • Int'l Joint Research
• [Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats (2016)
  • Author(s): Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: The 9th International PCB Workshop
  • Place of Presentation: Kobe International Conference Center, Kobe, Japan
  • Year and Date: 2016-10-09
  • Int'l Joint Research
• [Presentation] Toxicological assessment of PCBs and OH-PCBs in the brain of dogs using metabolomics approach (2016)
  • Author(s): Kei Nomiyama, Kohki Takaguchi, Akifumi Eguchi, Hazuki, Mizukawa, Jean, Yoo, Saya, Tamura, Tomoko, Oshihoi, Hisato, Iwata, Tatsuya, Kunisue, Shinsuke Tanabe
  • Organizer: The 9th International PCB Workshop
  • Place of Presentation: Kobe International Conference Center, Kobe, Japan
  • Year and Date: 2016-10-09
  • Int'l Joint Research
• [Presentation] Disruption of mitochondrial functions by PCB exposure in the dog brain: Toxicological assessment using cross omics (2016)
  • Author(s): Kohki Takaguchi, Kei Nomiyama, Akifumi Eguchi, Lauan Maria Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: The 9th International PCB Workshop
  • Place of Presentation: Kobe International Conference Center, Kobe, Japan
  • Year and Date: 2016-10-09
  • Int'l Joint Research
• [Presentation] 野生げっ歯類の殺鼠剤の抵抗性メカニズムと非対象動物に対する毒性メカニズム (2016)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 日本哺乳類学会2016年度大会「企画シンポジウム：野生動物が関わる問題にどのように対応するか？～基礎研究を応用した解決への取り組み～」
  • Place of Presentation: 筑波大学、つくば市、茨城県
  • Year and Date: 2016-09-23
• [Presentation] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~ (2016)
  • Author(s): Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] UGT2Bサブファミリーに着目した食肉目におけるグルクロン酸抱合能の動物種差解明 (2016)
  • Author(s): 近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
  • Organizer: 平成28年度内外環境応答・代謝酵素研究会
  • Place of Presentation: 静岡県立大学薬学部、静岡市、静岡県
  • Year and Date: 2016-09-17
• [Presentation] 野生動物及び実験動物におけるグルクロン酸抱合酵素の動物種差解明 (2016)
  • Author(s): 近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06
• [Presentation] 犬と猫の慢性腎臓病における尿細管周囲毛細血管の変化 (2016)
  • Author(s): 中村麗菜、矢吹 映、市居 修、水川葉月、横山 望、大和 修
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06
• [Presentation] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs (2016)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research
• [Presentation] クロスオミックスによるイヌ脳の PCBs 毒性評価（Cross omics analysis for PCBs toxicity in the dog brain） (2016)
  • Author(s): 髙口倖暉、野見山桂、Lauan Maria Claret、Yoo Jean、水川葉月、岩田久人、国末達也、田辺信介
  • Organizer: 日本プロテオーム学会2016年大会
  • Place of Presentation: 北里大学、東京都港区
  • Year and Date: 2016-07-28
• [Presentation] ハリネズミは化学物質高感受性種？ African hedgehog (Atalerix albiventris)で観察された低薬物代謝能 (2016)
  • Author(s): アクソルン サエンティエンチャイ、池中 良徳、ネスタ サム、ウスマ ジャムナーク、水川 葉月、中山 翔太、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋、愛知
  • Year and Date: 2016-06-29
• [Presentation] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 水川 葉月、前原 美咲、横山 望、市居 修、滝口 満喜、野見山 桂、西川 博之、池中 良徳、中山 翔太、高口 倖暉、田辺 信介、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋、愛知
  • Year and Date: 2016-06-29
• [Presentation] UGTの動物種差 (2016)
  • Author(s): 石塚 真由美、中山 翔太、水川 葉月、池中 良徳
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋、愛知
  • Year and Date: 2016-06-29
• [Presentation] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
  • Organizer: 第43回日本毒性学会
  • Place of Presentation: ウィングあいち、愛知
  • Year and Date: 2016-06-29
• [Presentation] ネコにおけるポリ塩化ビフェニル（PCBs）の異物代謝機構解明と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-06-08
• [Presentation] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 野見山 桂、山本 恭央、水川 葉月、江口 哲史、滝口 満喜、中山 翔太、池中 良徳、石塚 真由美、国末 達也、田辺 信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-06-08
• [Presentation] メタボローム解析を用いたPCBsによるイエネコの毒性影響評価 (2016)
  • Author(s): 西川博之、野見山桂、水川葉月、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-06-08
• [Presentation] クロスオミックスによるイヌ脳へのPCBs毒性評価：ミトコンドリア機能へ及ぼす影響解析 (2016)
  • Author(s): 高口 倖暉、野見山 桂、Lauan Maria Claret、草木 桃子、Yoo Jean、水川 葉月、岩田 久人、国末 達也、田辺 信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-06-08
• [Presentation] メタボロミクスアプローチを用いたイヌ脳へのOH-PCBs毒性機序の解明 (2016)
  • Author(s): 野見山 桂、高口 倖暉、江口 哲史、水川 葉月、Yoo Jean、田村 沙弥、忍穂井 智子、岩田 久人、国末 達也、田辺 信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-06-08
• [Presentation] 非実験動物における化学物質代謝能の特徴と種差 (2016)
  • Author(s): 池中良徳、筧麻友、水川葉月、中山翔太、石塚真由美
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] BIOTRANSFORMATION POTENCIES OF POLYCHROLINATED BIPHENYLS IN CATS (2016)
  • Author(s): Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: INTERNATIONAL SYMPOSIUM ON ENVIRONMENTAL CHEMISTRY AND TOXICOLOGY – TO ACCELERATE A GLOBAL NETWORK OF ENVIRONMENTAL RESEARCHERS
  • Place of Presentation: Matsuyama, Ehime, Japan
  • Year and Date: 2016-03-19
  • Int'l Joint Research
• [Presentation] 化学物質の汚染環境に生きる野生動物の適応戦略 (2016)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 一般社団法人日本環境化学会25周年記念講演会：「環境化学の今、そして未来へ－環境化学からの提言－」
  • Place of Presentation: 発明会館地下ホール、東京都港区
  • Invited
• [Presentation] Metabolism and biotransformation of organohalogen compounds in the liver microsomes of cats and dogs (2015)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Nozomu, Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama,Misaki Maehara, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: SETAC North America 36th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center, Salt Lake City, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Omics approach of proteomic and metabolomic analysis for PCBs toxicity in the dog brain (2015)
  • Author(s): Kohki Takaguchi, Kei Nomiyama, Lauan M. Claret, Momoko Kusaki, Jean Yoo, Hazuki Mizukawa, Hisato Iwata, Tatsuya Kunisue, Shinsuke Tanabe.
  • Organizer: SETAC North America 36th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center, Salt Lake City, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats: effects on thyroid hormones homeostasis (2015)
  • Author(s): Yasuo Yamamoto, Kei Nomiyama, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Tatsuya Kunisue, Shinsuke Tanabe
  • Organizer: SETAC North America 36th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center, Salt Lake City, USA
  • Year and Date: 2015-11-01
  • Int'l Joint Research
• [Presentation] Phase II xenobiotic metabolizm in carnivora -UGT activity and genomestructure in Pinniped species- (2015)
  • Author(s): Yoshinori Ikenaka, Mayu Kakehi, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 7th SETAC Africa Conference
  • Place of Presentation: Langebaan, South Africa
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] 第 II 相抱合反応の種差：食肉目におけるグルクロン酸抱合酵素の進化と遺伝子構造 (2015)
  • Author(s): 池中良徳 、筧 麻友、中山翔太、川合佑典、渡邊研右、水川葉月、野見山 桂、田辺信介、石塚真由美
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-06-24
• [Presentation] メタボローム解析によるイヌ脳中PCBs, OH-PCBsの毒性影響評価 (2015)
  • Author(s): 野見山 桂、江口哲史、水川葉月、Yoo Jean、高口倖暉、山本泰央、忍穂井 智子、岩田久人、国末達也、田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-06-24
• [Presentation] ポリ塩化ビフェニル（PCBs）を曝露したイヌの脳プロテオーム解析による毒性影響評価 (2015)
  • Author(s): 高口倖暉、野見山桂、Lauan Maria Claret 、草木桃子、Yoo Jean、水川葉月、岩田久人、国末達也、田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-06-24
• [Presentation] ポリ塩化ビフェニル（PCBs）曝露によるイヌ異物代謝酵素シトクロムP450発現への影響評価 (2015)
  • Author(s): 田村沙弥、劉 珍、水川葉月、阿草哲郎、平野将司、野見山 桂、田辺信介、金 恩英、岩田久人
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-06-24
• [Presentation] ペットネコにおける有機ハロゲン化合物および水酸化代謝物の汚染実態と甲状腺ホルモン恒常性への影響 (2015)
  • Author(s): 山本恭央、野見山桂、水川葉月、滝口満喜、石塚真由美、国末達也、田辺信介
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2015-06-24
• [Remarks] 北海道大学大学院獣医学研究院毒性学教室HP
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] 海道大学大学院獣医学研究院毒性学教室Facebook
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• [Remarks] 北海道大学大学院獣医学研究院毒性学教室Facebook
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• [Remarks] 北海道大学大学院獣医学研究科毒性学教室HP
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] 北海道大学大学院獣医学研究科毒性学教室Facebook
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