Risk assessment of cardiovascular toxicity by atmospheric microparticles
| Project/Area Number |
15K16148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
onodera akira 神戸学院大学, 薬学部, 助教 (40598380)
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| Research Collaborator |
Kawai Yuichi 神戸学院大学, 薬学部, 教授 (00102921)
Kawai Yuichi 神戸学院大学, 薬学部, 教授 (30248108)
Taniguchi Kosuke 神戸学院大学, 薬学部, 学部学生
Morikawa Arisa 神戸学院大学, 薬学部, 学部学生
Kawasaki Masashi 神戸学院大学, 薬学部, 学部学生
Isaki Yasunori 神戸学院大学, 薬学部, 学部学生
Fujii Ayako 神戸学院大学, 薬学部, 学部学生
Matsuda Shinya 神戸学院大学, 薬学部, 学部学生
Morita Akane 神戸学院大学, 薬学部, 学部学生
Ohmae Takuya 神戸学院大学, 薬学部, 学部学生
Korai Asaka 神戸学院大学, 薬学部, 学部学生
Miyake Akiho 神戸学院大学, 薬学部, 学部学生
Morisawa Mio 神戸学院大学, 薬学部, 学部学生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管弛緩 / カルシウム / PI3Kシグナル / 高血圧 / PI3K / レニン / 血圧 / 心拍 / 血管収縮 |
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| Outline of Final Research Achievements |
This epidemiological investigation is concerned with the increase in death rate due to respiratory or cardiac diseases caused by atmospheric microparticles. Atmospheric microparticles can be as large as 10 μm and as small as 100 nm in size. The strength of the cardiovascular toxicity is considered to be inversely proportional to the size of the particle.
In the present study, we succeeded in finding two new results by analyses using silica particles and zinc oxide particles as model materials. In the analysis using silica particles, particles less than 70 nm in diameter relaxed blood vessels via the PI3K signaling pathway. In the analysis using zinc oxide particles, particles less than 100 nm in diameter caused high blood pressure via the renin-angiotensin system.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Amorphous nanosilica particles evoke vascular relaxation through PI3K/Akt/eNOS signaling.2016
Author(s)
Onodera A, Yayama K, Tanaka A, Morosawa H, Furuta T, Takeda N, Kakiguchi K, Yonemura S, Yanagihara I, Tsutsumi Y, Kawai Y.
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Journal Title
Fundam Clin Pharmacol.
Volume: 30
Issue: 5
Pages: 433-439
DOI
Related Report
Peer Reviewed
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[Journal Article] Short-term changes in intracellular ROS localisation after thesilver nanoparticles exposure depending on particle size2015
Author(s)
Akira Onodera, Fumiko Nishiumi, Kisa Kakiguchi, Atsushi Tanaka,Nami Tanabe, Aki Honma, Katsutoshi Yayama, Yasuo Yoshioka,Kumiko Nakahira, Shigenobu Yonemura, Itaru Yanagihara,Yasuo Tsutsumi, Yuichi Kawai
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Journal Title
Toxicology Reports
Volume: 2
Pages: 574-579
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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