Regulation of absorptive function via THRSP in the small intestine and the development for risk reduction of cardiovascular disease

Research Project

Project/Area Number	15K16205
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits
Research Institution	Gifu University
Principal Investigator	SHIMADA Masaya 岐阜大学, 応用生物科学部, 准教授 (10576755)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	THRSP / フルクトース / ChREBP / 肝臓 / 糖輸送体
Outline of Final Research Achievements	We examined the relationship between a transcription factor THRSP and genes related to carbohydrate digestion/absorption in the small intestine and to fatty acid synthesis in the liver. Small intestinal expression of GLUT5 gene, not THRSP gene is significantly higher in rats fed a high-fructose diet than those fed a high-glucose diet. Hepatic expression of THRSP gene as well as fatty acid synthesis genes (ACACA, FASN, SCD1) is significantly higher in rats fed a high-fructose diet than those fed a high-glucose diet.

Report

(4 results)