The role of ER stress in fatty liver: Identification of novel fatty acid sensing molecule
| Project/Area Number |
15K16208
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2017)
The University of Tokushima (2015-2016) |
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Principal Investigator |
ABE TOMOKI 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (00736605)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪肝 / ユビキチンリガーゼ / 小胞体ストレス / 脂肪合成 / Cbl-b / ミトコンドリア / 小胞体 / 高脂肪食 |
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| Outline of Final Research Achievements |
Fatty liver is associated with cirrhosis and hepatic cacinoma, although molecular mechanisms for fatty liver remain unclear. The aim of this study was to elucidate the pathophysiological role of Cbl-b, one of ubiquitin ligases in the fatty liver induced by nutritional excess in mice. I found that depletion of Cbl-b exacerbate fatty liver in mice fed high-fat diet for 8 weeks. In livers of Cbl-b deficient mice, ER stress and expressions of lipogenesis-associated genes were upregulated. Cbl-b might be a potent target to prevent and improve for fatty liver.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Capric acid up-regulates UCP3 expression without PDK4 induction in mouse C2C12 myotubes2016
Author(s)
Tomoki Abe, Katsuya Hirasaka, Shohei Kohno, Chisato Tomida, Marie Haruna, Takayuki Uchida, Ayako Ohno, Motoko Oarada, Shigetada Teshima-Kondo, Yuushi Okumura, Inho Choi, Toshiaki Aoyama, Junji Terao, Takeshi Nikawa
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 62
Pages: 32-39
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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