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Establishment of a system for screening food factors inhibiting the absorption of Cs in intestine

Research Project

Project/Area Number 15K16211
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionSugiyama Jogakuen University (2017-2018)
University of Shizuoka (2015-2016)

Principal Investigator

Yasuda Michiko  椙山女学園大学, 生活科学部, 講師 (00707036)

Research Collaborator Shimoi Kayoko  
Karaki Shin-ichiro  
Masuda Syuichi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsセシウム / 腸管 / Caco-2細胞 / 食品機能 / ケルセチン / ゲニステイン / グルカン / Caco-2 / 吸収阻害 / 排泄促進 / フラボノイド / Ussing chamber / 食品汚染 / 内部被ばく / グリコーゲン / 食品成分
Outline of Final Research Achievements

The aim of this study was the establishment of a system for screening food factors inhibiting the absorption of Cs in intestine and the investigation of food factors using Caco-2 cell system in tissue culture insert, a well characterized intestinal in vitro model, and the Ussing chamber system equipped with intestinal tissue from C57BL/6 mice. CsCl solution was added to apical side in Caco-2 system. After incubation for various lengths of time, aliquots of the buffer in opposite chambers are removed, and digested with a microwave digestion procedure for the determination of Cs concentration by ICP-MS. In Ussing chamber system with mouse jejunum, CsCl solution (1.0 mM) was added to mucosal side, and aliquots of the buffer in opposite chambers are corrected after incubation and digested as above. In summary, we developed the system for screening food factors inhibiting the absorption of Cs in intestine, and investigated the effects of food flavonoids on these evaluation systems.

Academic Significance and Societal Importance of the Research Achievements

摂取することで放射性セシウムによる内部被ばくを防ぐ薬剤のプルシアンブルーとリンゴのペクチンには研究成果報告に示したように問題点がある。本研究により、まず、これらの問題点を解決するための食品成分に関する検討が可能になる。また、これを使って、実際にセシウムの腸管での移行を調節する食品成分を得られた場合、ヒトへの内部被ばく対策として用いることができると共に、食用動物等にも応用できる可能性がある。また、風評被害を含め、放射性物質による事故の際の食材に対する風評被害も含めた、人々への不安軽減にも役立つことが考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid2017

    • Author(s)
      Yasuda MT, Sakakibara H, Shimoi K
    • Journal Title

      Genes Environ.

      Volume: 39(10) Issue: 1 Pages: 1-9

    • DOI

      10.1186/s41021-016-0071-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Adsorptive Property of Food Materials and Chemicals to Cesium and Strontium.2017

    • Author(s)
      Uehara Y, Ishizuka K, Shimamura Y, Yasuda M, Shimoi K, Masuda S
    • Journal Title

      Nat. Prod. Commun.

      Volume: 12(2) Pages: 263-265

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploration of food materials and components showing the suppressing effect on absorption of strontium and the promoting effect on excretion of cesium in vivo.2016

    • Author(s)
      Uehara Y, Ishizuka K, Shimamura Y, Yasuda M, Shimoi K, Masuda S
    • Journal Title

      Integr. Cancer Sci. Ther.

      Volume: 3(6) Issue: 6 Pages: 1-4

    • DOI

      10.15761/icst.1000216

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Establishment of a system for screening food factors inhibiting the absorption of Cs in intestine2018

    • Author(s)
      Michiko T Yasuda, Chika Tokuyama, Yukiko Kobayashi, Sachiyo Shitasue, Shin-Ichiro Karaki, Kayoko Shimoi
    • Organizer
      the 256th ACS National Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 消化管粘膜上皮による管腔内化学物質受容と粘膜機能(分泌・バリア機能)への影響2018

    • Author(s)
      唐木晋一郎、保田倫子
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 放射性セシウムによる内部被ばくを防ぐ食品成分探索のための評価系2017

    • Author(s)
      保田倫子、徳山千佳、唐木晋一郎、下位香代子
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-20
    • Related Report
      2016 Research-status Report
  • [Presentation] セシウムおよびストロンチウムによる内部被曝を軽減化する食品素材・成分の探索2017

    • Author(s)
      上原祐也、石塚加奈、島村裕子、保田倫子、下位香代子、増田修一
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 腸管を介したセシウム移行に食品因子が及ぼす効果2017

    • Author(s)
      保田倫子、徳山千佳、唐木晋一郎、下位香代子
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 消化管粘膜上皮による管腔内化学物質受容と上皮膜機能調節機構2016

    • Author(s)
      唐木晋一郎、保田倫子
    • Organizer
      第22回Hindgut Club Japanシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 放射性物質による内部被爆を防ぐ食品素材・成分の探索2016

    • Author(s)
      上原祐也、石塚加奈、島村裕子、保田倫子、下位香代子、増田修一
    • Organizer
      第71回 日本栄養・食糧学会中部支部大会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] セシウムの腸管における透過に関する評価系の確立2016

    • Author(s)
      保田倫子、唐木晋一郎、下位香代子
    • Organizer
      第21回日本フードファクター学会(JSoFF2016)
    • Place of Presentation
      冨山
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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