| Project/Area Number |
15K16321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルツハイマー病 / 分子イメージング / 老人斑 / 神経原線維変化 / フッ素MRI / 画像解析 / MRI |
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| Outline of Final Research Achievements |
In this project, we have synthesized Shiga-X33 as a novel 19F-MR probe which can be used for amyloid imaging. MR measurement using Shiga-X33 showed high accumulation of 19F-MR signals in the brain of APP/PS1 transgenic mice. Furthermore, we synthesized Shiga-X35 as another novel 19F-MR probe for tau imaging. MR measurement using Shiga-X35 showed high accumulation of the 19F-MR signals in the brain of rTg4510 tau transgenic mice. Structurally, Shiga-X33 has a CHF2 group which shows 19F chemical shift of -126 ppm. Meanwhile, Shiga-X35 has a CF3 group which shows 19F chemical shift of -75 ppm. There is sufficient difference of 19F chemical shift value between Shiga-X33 and Shiga-X35 to make images simultaneously for both 19F-MR signals by chemical shift imaging. Altogether, we have succeeded in developing the probes for simultaneous detection of amyloid and tau using 19F-MRI.
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