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Study of the way of dietary modification to decrease arterial stiffness and increase cirrculating Pentraxin3 levels

Research Project

Project/Area Number 15K16519
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionRyutsu Keizai University

Principal Investigator

Zempo Asako  流通経済大学, スポーツ健康科学部, 准教授 (50734141)

Project Period (FY) 2015-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生活習慣 / 食事 / 運動 / 肥満 / 炎症 / 減量 / 食物摂取頻度調査 / 抗炎症性因子 / ペントラキシン3 / 横断研究 / PTX3濃度 / PTX3 / 生活習慣改善 / 介入研究 / 食事改善 / 動脈硬化度 / 食事バランス / 動脈硬化
Outline of Final Research Achievements

In this study, I planned to demonstrate the usefulness of circulating levels of pentraxin-3 (PTX3) as an index reflecting arterial stiffness conditioning in humans. As PTX3 is known as a protein with anti-inflammatory effects, I hypothesized that some positive dietary habits may increase its levels in healthy individuals. First, in a cross-sectional study including over 400 subjects, which I plan to publish as an international accomplishment, I attempted to demonstrate the characteristics of dietary habits to obtain higher plasma PTX3 levels. Second, in an interventional study, I observed the effect of PTX3 after weight-loss through dietary modification in overweight and obese men. I have already published these results in the international academic journal Applied Physiology, Nutrition, and Metabolism.

Academic Significance and Societal Importance of the Research Achievements

心血管疾患は我が国の死因上位であり、食習慣がこの疾患リスクを増大させることはすでに明らかである。しかし、それを具体的な指標である血中物質をターゲットとして横断的あるいは介入によってその動態について検討し、臨床においての有用性を示した点で社会的意義が大きいと考える。横断的研究については未発表であるものの、論文化して本研究によるデータをまとめて報告しようとしている点、さらには、介入研究の成果についてはすでに著明な査読付き国際誌に筆頭著者として公表した点でもその学術的意義は大きいと考える。

Report

(7 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (45 results)

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 20 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Changes in plasma amino acid concentrations in overweight and obese men after weight loss program including dietary modification and aerobic exercise2020

    • Author(s)
      Kanae Myoenzono, Toru Yoshikawa, Hiroshi Kumagai, Asako Zempo-Miyaki, Rina So, Takehiko Tsujimoto, Youngju Choi, Kiyoji Tanaka, Seiji Maeda
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 9 Issue: 2 Pages: 43-51

    • DOI

      10.7600/jpfsm.9.43

    • NAID

      130007807104

    • ISSN
      2186-8123, 2186-8131
    • Year and Date
      2020-03-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined aerobic and low-intensity resistance exercise training increases basal nitric oxide production and decreases arterial stiffness in healthy older adults2020

    • Author(s)
      Takeshi Otsuki, Hayate Namatame, Toru Yoshikawa and Asako Zempo-Miyaki
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 66 Issue: 1 Pages: 62-66

    • DOI

      10.3164/jcbn.19-81

    • NAID

      130007779225

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitric oxide and decreases in resistance exercise blood pressure with aerobic exercise training in older individuals2019

    • Author(s)
      Takeshi Otsuki,Fumiko Nakamura,Asako Zempo-Miyaki
    • Journal Title

      Front. Physiol.

      Volume: 10 Pages: 1204-1204

    • DOI

      10.3389/fphys.2019.01204

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of High Physical Fitness in Deterioration of Male Sexual Function in Japanese Adult Men.2019

    • Author(s)
      Kumagai H, Yoshikawa T, Myoenzono K, Kosaki K, Akazawa N, Tanahashi K, Tagawa K, Zempo-Miyaki A, Maeda S.
    • Journal Title

      American Journal of Men's Health

      Volume: 13 Issue: 3 Pages: 1-9

    • DOI

      10.1177/1557988319849171

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Curcumin supplementation attenuates a decrease in endothelial function following eccentric exercise.2019

    • Author(s)
      Choi Y, Tanabe Y, Akazawa N, Zempo-Miyaki A, Maeda S.
    • Journal Title

      Journal of Exercise Nutrition and Biochemistry

      Volume: 23 Issue: 2 Pages: 7-12

    • DOI

      10.20463/jenb.2019.0010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training.2019

    • Author(s)
      Zempo-Miyaki A, Kumagai H, Yoshikawa T, Myoenzono K, So R, Otsuki T, Tanaka K, Maeda S.
    • Journal Title

      Applied Physiology Nutrition and Metabolism

      Volume: 44 Issue: 2 Pages: 111-117

    • DOI

      10.1139/apnm-2018-0214

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vigorous physical activity is associated with regular aerobic exercise-induced increased serum testosterone levels in overweight/obese men.2018

    • Author(s)
      Kumagai H, Yoshikawa T, Zempo-Miyaki A, Myoenzono K, Tsujimoto T, Tanaka K, Maeda S.
    • Journal Title

      Hormone and Metabolic Research

      Volume: 50 Issue: 01 Pages: 73-79

    • DOI

      10.1055/s-0043-117497

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification2018

    • Author(s)
      Yoshikawa T, Zempo-Miyaki A, Kumagai H, Myoenzono K, So R, Tsujimoto T, Tanaka K, Maeda S.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 3 Pages: 254-258

    • DOI

      10.3164/jcbn.17-103

    • NAID

      130006730765

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of leg heating on central hemodynamics in postmenopausal women.2018

    • Author(s)
      Kosaki K, Sugawara J, Zempo-Miyaki A, Maeda S.
    • Journal Title

      Artery Research

      Volume: 21 Issue: C Pages: 53-57

    • DOI

      10.1016/j.artres.2018.01.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of <i>Chlorella</i>-derived multicomponent supplementation on maximal oxygen uptake and serum vitamin B<sub>2</sub> concentration in young men2017

    • Author(s)
      Zempo-Miyaki A, Maeda Seiji, Otsuki Takeshi.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 61 Issue: 2 Pages: 135-139

    • DOI

      10.3164/jcbn.17-36

    • NAID

      130006038750

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Central blood pressure is associated with trunk flexibility in older adults.2017

    • Author(s)
      Komatsu M, Akazawa N, Tanahashi K, Kumagai H, Yoshikawa T, Kosaki K, Zempo-Miyaki A, Maeda S.
    • Journal Title

      Artery Research

      Volume: 19 Issue: C Pages: 91-96

    • DOI

      10.1016/j.artres.2017.07.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men.2017

    • Author(s)
      Yoshikawa T, Kumagai H, Myoenzono K, Zempo-Miyaki A, Tsujimoto T, Tanaka K, Maeda S.
    • Journal Title

      Artery Research

      Volume: 20 Issue: C Pages: 27-34

    • DOI

      10.1016/j.artres.2017.10.199

    • Related Report
      2017 Research-status Report
  • [Journal Article] ライフセーバーにおける水難救助活動期間中の睡眠と唾液SIgA分泌速度との関連.2017

    • Author(s)
      荒井宏和,大槻毅,清水和弘,花岡裕吉,膳法亜沙子,崔英珠,渡部厚一,前田清司.
    • Journal Title

      日本臨床スポーツ医学会誌

      Volume: 25

    • NAID

      40021212910

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone2016

    • Author(s)
      Kumagai H, Zempo-Miyaki A, Yoshikawa T, Tsujimoto T, Tanaka K, Maeda S.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 1 Pages: 84-89

    • DOI

      10.3164/jcbn.15-48

    • NAID

      130005116626

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Habitual exercise decreases systolic blood pressure during low-intensity resistance exercise in healthy middle-aged and older individuals2016

    • Author(s)
      Otsuki T, Kotato T, Zempo-Miyaki A.
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 311 Issue: 4 Pages: H1024-H1030

    • DOI

      10.1152/ajpheart.00379.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] (研究報告)小・中学生の柔軟性は発育発達に伴い増大するか.2016

    • Author(s)
      宿谷あゆみ, 小粥智浩, 膳法亜沙子, 大槻毅.
    • Journal Title

      体育の科学

      Volume: 67 Pages: 133-138

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults.2016

    • Author(s)
      Zempo-Miyaki A, Fujie S, Sato K, Hasegawa N, Sanada K, Maeda S, Hamaoka T, Iemitsu M
    • Journal Title

      Journal of Human Hypertension

      Volume: 未定 Issue: 9 Pages: 521-526

    • DOI

      10.1038/jhh.2015.105

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of static squat exercise with whole body vibration on arterial stiffness in older women.2016

    • Author(s)
      Sawano Y, Zempo-Miyaki A, Akazawa N,Kosaki K, So R, Tanaka K, Maeda S.
    • Journal Title

      Advances in Exercise and Sports Physiology

      Volume: 22 Pages: 13-17

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in salivary flow rate following Chlorella-derived multicomponent supplementation.2016

    • Author(s)
      Otsuki T, Shimizu K, Zempo-Miyaki A, Maeda S.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 未定 Issue: 1

    • DOI

      10.1186/1475-2891-10-91

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lifestyle modification decreases arterial stiffness in overweight and obese men: dietary modification vs. exercise training.2015

    • Author(s)
      Maeda S, Miyaki A, Sasai H, Tsujimoto T, So R, Tanaka K
    • Journal Title

      International Journal of Sport Nutrition & Exercise Metabolism

      Volume: 25(1) Issue: 1 Pages: 69-77

    • DOI

      10.1123/ijsnem.2013-0107

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin2015

    • Author(s)
      Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuku Y, Nosaka K.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 115 Issue: 9 Pages: 1149-1157

    • DOI

      10.1007/s00421-015-3170-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 成人肥満男性における有酸素性運動トレーニングが血中PTX3濃度に与える影響2020

    • Author(s)
      膳法亜沙子、吉川徹、妙圓園香苗、朴ジヨン、田中喜代次、前田清司
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] シンポジウム3「人生100年時代におけるサクセスフルエイジングのための生活習慣」 ~サクセスフルエイジングのための中高齢者に望ましい食事と栄養を考える~2020

    • Author(s)
      膳法亜沙子
    • Organizer
      第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 水中運動におけるリラクセーション効果の検討 ~心臓自律神経活動に着目して~2019

    • Author(s)
      青葉貴明、中村芙美子、生田目颯、塚本教貴、膳法亜沙子、大槻毅
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 細菌感染前の単回運動が与える抗炎症効果―PTX3に着目して―2019

    • Author(s)
      膳法 亜沙子、下條信威、松原朋子、前田清司
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肥満男性における12週間の食習慣改善または有酸素性運動が 糖負荷前後の中心血圧に与える影響2019

    • Author(s)
      吉川徹, 熊谷仁, 妙圓園香苗, 膳法亜沙子, 辻本健彦, 田中喜代次, 前田清司
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of aerobic exercise on plasma 3-Hydroxyisobutyrate level in overweight and obese men. -Comparison between non-IR, pre-IR and IR-2019

    • Author(s)
      Kanae Myoenzono, Toru Yoshikawa, Jiyeon Park, Asako Zempo-Miyaki, Teruo Miyazaki, Akira Honda, Nobutake Shimojo, Seiji Maeda
    • Organizer
      The 23nd Annual Congress of the European College of Sport Science
    • Related Report
      2019 Research-status Report
  • [Presentation] Decreases in resistance exercise SBP by aerobic training is associated with nitric oxide in older individuals2019

    • Author(s)
      Takeshi Otsuki, Fumiko Nakamura, Asako Zempo-Miyaki
    • Organizer
      The 23nd Annual Congress of the European College of Sport Science
    • Related Report
      2019 Research-status Report
  • [Presentation] Habitual exercise decreases systolic blood pressure during low-intensity resistance exercise in middle-aged and older individuals.2017

    • Author(s)
      Takeshi Otsuki, Takahiro Kotato, Asako ZempoMiyaki.
    • Organizer
      The 22nd Annual Congress of the European College of Sport Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満者における生活習慣改善が動脈スティフネスと炎症性因子に及ぼす影響.2017

    • Author(s)
      熊谷仁、膳法亜沙子、吉川徹、蘇りな、西保岳、田中喜代次、前田清司.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 男性機能の低下は中心動脈スティフネスの増大と関連する.2017

    • Author(s)
      熊谷 仁、吉川 徹、妙圓園香苗、小崎恵生、赤澤暢彦、膳法(宮木)亜沙子、辻本健彦、田中喜代次、前田清司.
    • Organizer
      第5回日本介護福祉・健康づくり学会.
    • Related Report
      2017 Research-status Report
  • [Presentation] クロレラ由来の総合栄養サプリメントが最大酸素摂取量および唾液SIgA分泌速度を増加させる機序の解明-;炎症性物質の網羅的解析による検討-2017

    • Author(s)
      膳法亜沙子,山田睦雄,奥村衣梨,大槻毅.
    • Organizer
      第28回日本臨床スポーツ医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 閉経後女性における骨代謝とAIの関連性-運動トレーニングが及ぼす影響2016

    • Author(s)
      澤野友里子、膳法亜沙子、棚橋嵩一郎、小崎恵生、赤澤暢彦、前田清司.
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満男性における有酸素性運動と食習慣改善が血中テストステロン濃度に及ぼす影響の比較.2016

    • Author(s)
      熊谷仁、吉川徹、膳法亜沙子、妙圓園香苗、辻本健彦、田中喜代次、前田清司.
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 有酸素性トレーニングが一過性の有酸素性運動後の脳血流拍動性に及ぼす影響.2016

    • Author(s)
      赤澤暢彦、棚橋嵩一郎、小崎惠生、羅成圭、松原朋子、崔英珠、膳法亜沙子、前田清司.
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 定期的な有酸素性運動が血中テストステロン濃度に及ぼす影響肥満男性と非肥満男性における検討.2016

    • Author(s)
      熊谷仁、吉川徹、膳法亜沙子、妙圓園香苗、辻本健彦、田中喜代次、前田清司.
    • Organizer
      第24回日本運動生理学会学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Aerobic exercise training increases testosterone production in the testis in OLETF rat2016

    • Author(s)
      Hiroshi Kumagai, Asako Zempo-Miyaki, Kanae Myouenzono, Seiji Maeda.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego
    • Year and Date
      2016-04-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] クロレラ由来の総合栄養サプリメントによる最大酸素摂取量の変動と食習慣および血清ビタミンB2濃度.2015

    • Author(s)
      大槻 毅、膳法亜沙子、荒川ゆかり、山田 睦雄.
    • Organizer
      第26回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 肥満男性における食事改善、有酸素性運動、食事改善と有酸素性運動の併用が中心および末梢動脈スティフネスに与える影響2015

    • Author(s)
      膳法(宮木)亜沙子,蘇リナ,熊谷仁,田中喜代次,下條信威,前田清司
    • Organizer
      第28回日本体力医学会奨励賞授賞式
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 肥満男性における定期的な有酸素性運動が脈圧増幅に与える影響.2015

    • Author(s)
      吉川徹、膳法亜沙子、熊谷仁、辻本健彦、田中喜代次、前田清司.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 肥満者における生活習慣改善が動脈スティフネスと炎症性因子に及ぼす影響2015

    • Author(s)
      熊谷仁、膳法亜沙子、吉川徹、蘇りな、西保岳、田中喜代次、前田清司.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 中高齢女性における下肢温熱が動脈スティフネスに及ぼす影響2015

    • Author(s)
      小崎恵生、膳法亜沙子、赤澤暢彦、松原朋子、菅原順、前田清司.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 中高齢女性における全身振動刺激を用いた一過性の静的スクワット運動はAugmentation Indexを低下させる.2015

    • Author(s)
      澤野友里子、膳法亜沙子、赤澤暢彦、小崎恵生、蘇リナ、田中喜代次、前田清司.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 食事改善および運動習慣化が 動脈スティフネスに与える影響2015

    • Author(s)
      膳法亜沙子
    • Organizer
      平成27年度運動と循環の研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Remarks] Research map

    • URL

      https://researchmap.jp/azempo-miyaki

    • Related Report
      2020 Annual Research Report

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Published: 2015-04-16   Modified: 2022-11-04  

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