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Seasonal differences of adipokine concentration in obese and diabetes mellitus

Research Project

Project/Area Number 15K16529
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionAichi Medical University

Principal Investigator

Sato Maki  愛知医科大学, 医学部, 講師 (60351102)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生活習慣病 / 季節性リズム / アディポカイン / 時計遺伝子 / 肥満 / 高照度光 / 運動
Outline of Final Research Achievements

Disruption of circadian rhythms is associated with the risk of diseases including metabolic syndrome and cardiovascular diseases. We examined the effects of bright light exposure on blood glucose, heart rate and heart rate variability in obese subjects in summer and winter seasons, in addition to plasma adipokine concentration and saliva clock genes expressions. The blood glucose concentration and cardiac autonomic nervous activity were not significantly different during exercise under bright light exposure. Heart rate were elevated during exercise in obese in winter. Plasma TNF-α and IL-6 concentrations were not significantly different between obese and non-obese. Clock gene expressions were significantly decreased in obese than in non-obese in winter. These results suggested that short term exposure by bright light could not affect on blood glucose and cardiac autonomic nervous activity, while clock gene expressions were decreased in obese than in non-obese especially in winter.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Effects of bright light exposure during daytime on peripheral clock gene expression in humans.2017

    • Author(s)
      Sato Maki, Wakamura T, Morita T, Okamoto A, Akashi M, Matsui T, Sato Motohiko
    • Journal Title

      Int J Biometeorol.

      Volume: 印刷中 Issue: 6 Pages: 1133-1138

    • DOI

      10.1007/s00484-016-1294-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 肥満者および非肥満者での時計遺伝子発現の季節差2018

    • Author(s)
      佐藤麻紀、林寿来、池本辰則、牛田享宏、ドミニカ カニコフスカ、佐藤元彦
    • Organizer
      第95回日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥満者における唾液での時計遺伝子発現の季節性変動2017

    • Author(s)
      佐藤麻紀、林寿来、池本辰則、牛田享宏、佐藤元彦
    • Organizer
      第94回日本生理学会
    • Place of Presentation
      浜松アクトシティ
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Determination of seasonal differences of clock gene expressions in obese men using saliva sample2017

    • Author(s)
      Maki Sato, Hisaki Hayashi, Tatsunori Ikemoto, Takahiro Ushida, Dominika Kanikowska, Motohiko Sato
    • Organizer
      Experimental Biology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Seasonal differences in cardiac autonomic nervous activity during exercise in obese men2017

    • Author(s)
      Maki Sato, H Hayashi, T Ikemoto, Takahiro Ushida, Satoshi Iwase, Motohiko Sato
    • Organizer
      International Society for Autonomic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肥満者における唾液サンプルを用いた時計遺伝子発現の季節差2017

    • Author(s)
      佐藤麻紀、林寿来、池本辰則、牛田享宏、Dominika Kanikowska、佐藤元彦
    • Organizer
      第24回 日本時間生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Seasonal differences of clock gene expressions in buccal epithelial cells in obese men2017

    • Author(s)
      Maki Sato, Hisaki Hayashi, Tatsunori Ikemoto, Takahiro Ushida, Dominika Kanikowska, Motohiko Sato
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Seasonal differences in saliva melatonin concentrations and heart rate variability during sleep in obese men2015

    • Author(s)
      Maki Sato, D Kanikowska, S Iwase, Y Shimizu, N Nishimura, Y Inukai, M Sato, J Sugenoya
    • Organizer
      International Society for Autonomic Neuroscience
    • Place of Presentation
      ストレーザ(イタリア)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of light exposure during daytime on clock gene expression in hair follicular and root cells in humans2015

    • Author(s)
      Maki Sato, Tomoko Wakamura, Takeshi Morita, Akihiko Okamoto, Makoto Akashi, Takuya Matsui, Motohiko Sato
    • Organizer
      XIV European Biological Rhythms Society and IV World Congress of Chronobiology
    • Place of Presentation
      マンチェスター(イギリス)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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