| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Brain is a complex network of nerve cells. Neuronal culture has played important roles in the study of the nerve cells, but the innate difference in network architecture has hindered the wide-spread use of the culture system in the study of network functions. In the current project, we developed a series of surface engineering technologies to direct the spontaneous network formation by cultured neurons. This was realized at both the single-cellular and multi-cellular levels. We also developed a technology for amplifying weak signals of multi-electrode array recordings, that takes advantage of a cell sheet grown on a free-standing hydrogel membrane.
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