2017 Fiscal Year Final Research Report
Functional analysis of micropatterned neuronal networks using nano-structured electrodes
Project/Area Number |
15K17449
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Nanobioscience
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Research Institution | Tohoku University |
Principal Investigator |
Yamamoto Hideaki 東北大学, 学際科学フロンティア研究所, 助教 (10552036)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 神経回路網 / バイオインターフェース / 細胞パターニング / 微小電極アレイ / 細胞シート / 数理モデル / ソフトリソグラフィ |
Outline of Final Research Achievements |
Brain is a complex network of nerve cells. Neuronal culture has played important roles in the study of the nerve cells, but the innate difference in network architecture has hindered the wide-spread use of the culture system in the study of network functions. In the current project, we developed a series of surface engineering technologies to direct the spontaneous network formation by cultured neurons. This was realized at both the single-cellular and multi-cellular levels. We also developed a technology for amplifying weak signals of multi-electrode array recordings, that takes advantage of a cell sheet grown on a free-standing hydrogel membrane.
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Free Research Field |
ナノバイオサイエンス
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