Functional analysis of micropatterned neuronal networks using nano-structured electrodes
Project/Area Number |
15K17449
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Nanobioscience
|
Research Institution | Tohoku University |
Principal Investigator |
Yamamoto Hideaki 東北大学, 学際科学フロンティア研究所, 助教 (10552036)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 神経回路網 / バイオインターフェース / 細胞パターニング / 微小電極アレイ / 細胞シート / 数理モデル / ソフトリソグラフィ / 培養神経細胞 / 微細加工 / 複雑ネットワーク / モジュール構造 / 培養神経回路 / 自発活動 / 表面改質 / 多点電極アレイ / インピーダンス測定 / 生体絶縁膜 / ナノ加工 |
Outline of Final Research Achievements |
Brain is a complex network of nerve cells. Neuronal culture has played important roles in the study of the nerve cells, but the innate difference in network architecture has hindered the wide-spread use of the culture system in the study of network functions. In the current project, we developed a series of surface engineering technologies to direct the spontaneous network formation by cultured neurons. This was realized at both the single-cellular and multi-cellular levels. We also developed a technology for amplifying weak signals of multi-electrode array recordings, that takes advantage of a cell sheet grown on a free-standing hydrogel membrane.
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Report
(4 results)
Research Products
(81 results)