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Rare earth metal complex for multi-color multi-photon imaging

Research Project

Project/Area Number 15K17845
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional solid state chemistry
Research InstitutionYamaguchi University

Principal Investigator

Suzuki Yasutaka  山口大学, 大学院創成科学研究科, 准教授 (30634753)

Co-Investigator(Renkei-kenkyūsha) KAWAMATA JUN  山口大学, 大学院創生科学研究科, 教授 (40214689)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords多光子吸収 / 蛍光色素 / 発光生プローブ / 生体関連物質 / 非線形光学 / 多光子顕微鏡 / 発光性プローブ / 希土類金属錯体 / 生体イメージング / 多光子吸収現象 / 非線形光学材料 / 発光プローブ / 顕微鏡
Outline of Final Research Achievements

In this study, I aimed to achieve 3 dimensional multi-photon multi-color imaging of biological material by using coordination complex. During the project, I clarified the appropriate ligand for designing metal complex probe for deep tissue imaging. By using metal complex equipped with appropriate ligand, 1030 nm excited multi-photon imaging was experimentally achieved. In addition, I tried to further functionalization of metal complex. As a result, oxygen concentration monitoring by using multi-photon excitation microscope was achieved in living cell.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Biological oxygen sensing via two-photon absorption by an Ir(III) complex using a femtosecond fiber laser2016

    • Author(s)
      Morimoto H, Fujii A, Suzuki Y, Yoshihara T, Tobita S, Kawamata J
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 9 Pages: 092401-092403

    • DOI

      10.7567/jjap.55.092401

    • NAID

      210000147062

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-photon-induced Luminescence of Europium Acetylacetonate-type Complexes2016

    • Author(s)
      Y. Suzuki, H. Moritomo, A. Fujii, K. Satomi, J. Kawamata, M. Yamamoto, Y. Hasegawa
    • Journal Title

      Chemistry Letters

      Volume: 45 Issue: 5 Pages: 538-540

    • DOI

      10.1246/cl.160126

    • NAID

      130005150485

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] シアニン誘導体を用いたファイバーレーザーによる二光子励起イメージング2018

    • Author(s)
      大西省三、 松本和也、 浅村直哉、 守友博紀、 鈴木康孝、 川俣純
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア膜電位応答性を示す赤色蛍光プローブ2017

    • Author(s)
      浅村直哉、 大西省三、 関仁望、 仁子陽輔、 鈴木康孝、 川俣純
    • Organizer
      日本化学会中国四国支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 赤色発光性ピレン誘導体の二光子励起特性2017

    • Author(s)
      大西省三、 富永亮、 鈴木康孝、 川俣純、 仁子陽輔、 小西玄一
    • Organizer
      日本化学会「低次元系光機能材料研究会」第6回サマーセミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Luminescent molecular probes for multi-photon imaging2017

    • Author(s)
      Yasutaka Suzuki
    • Organizer
      Regius-200-Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Three-photon-induced Luminescence of Europium Acetylacetonate-type Complexes2015

    • Author(s)
      H. Moritomo, A. Fujii, T. Shiraishi, K. Satomi, H. Sugihara, Y. Suzuki, J. Kawamata
    • Organizer
      Pacifichem2015
    • Place of Presentation
      ハワイ、ホノルル、アメリカ
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient Two-Photon Fluorescent Molecules Excitable by a femtosecond Fiber Laser2015

    • Author(s)
      Y. Suzuki, H. Moritomo, A.Fuji, T. Shiraishi, J. Kawamata
    • Organizer
      第53回日本生物物理学会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] ミトコンドリア膜電位応答性蛍光化合物2017

    • Inventor(s)
      川俣純、鈴木康孝、浅村直也、仁子陽輔、関仁望
    • Industrial Property Rights Holder
      山口大学、高知大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-216664
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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