| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
This study focused on the process of the interaction. Since it is assumed that a small compound forms some intermediate states with various amino acids and finally binds to the energy-stable site of protein, the process is possibly differ among proteins. Here, the binding kinetic analysis was carried out to elucidate the binding process of the compound to protein. In this study, complexed energy transition in the binding process is simplified as two state reaction and the state where a compound is in process is regarded as transition state. From the analysis of thermodynamic parameters in transition state, the transition state is examined at amino acid level and the relationship between transition state and binding process is discussed. This allows us to verify the possibility of obtaining an important indicator for drug design.
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