| Project/Area Number |
15K17906
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Sawada Toshiki 東京工業大学, 物質理工学院, 助教 (20581078)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ハイドロゲル / 繊維状ウイルス / 液晶 / 抗体 / 分子徐放 / 遺伝子工学 / ソフトマテリアル / 生体高分子 / バイオテクノロジー / 分子認識 / ウイルス |
|---|
| Outline of Final Research Achievements |
For the purpose of construction of hydrogels with a capability to control the release of drug molecules with various properties, hydrogels containing filamentous viruses were performed. Gelatin molecules, which have a capability to form physically cross-linked network structures, were mixed with the viruses to form hydrogels. Genetically engineered viruses with an affinity for antibody proteins were mixed with gelatin and the antibody proteins, and the release of the antibody proteins were quantitatively investigated by enzyme-linked immunosorbent assay. As a result, it was found that the release of the antibody proteins were controlled by the amount of the peptide displayed on the viruses. Furthermore, release of two kinds of antibody proteins can be also controlled by using their specific peptide-displaying genetically engineered viruses.
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