Analysis of synapse dynamics receiving the different inputs
| Project/Area Number |
15K18360
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Tanaka Shinji 東京大学, 大学院医学系研究科(医学部), 助教 (60548494)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | in vivo imaging / スパイン / シナプス / イメージング / in vivoイメージング |
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| Outline of Final Research Achievements |
In this study, I examined the turnover rate of dendritic spines classified by the spatial location and synaptic marker. In vivo two-photon imaging of the somatosensory cortex showed that the turnover rate of dendritic spines was different between apical and basal dendrites of layer 2/3 pyramidal neurons. The stability of gephyrin-positive spines which are received the inputs from the thalamus, was substantially high both in apical and basal dendrites. Thus, the difference in spine turnover rate between apical and basal dendrites was attributed to the stability of gephyrin-negative spines. Since the apical and basal dendrites are reported to receive the inputs from different sources, these results suggest that the regulation of spine dynamics is different between the spines which receive the different inputs.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] In vivo observation of structural changes in neocortical catecholaminergic projections in response to drugs of abuse2018
Author(s)
Morimoto, M. Tanaka, S., Mizutani, S., Urata, S., Kobayashi, K., Okae, S.
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Journal Title
eNeuro
Volume: 6
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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