| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, I examined the turnover rate of dendritic spines classified by the spatial location and synaptic marker. In vivo two-photon imaging of the somatosensory cortex showed that the turnover rate of dendritic spines was different between apical and basal dendrites of layer 2/3 pyramidal neurons. The stability of gephyrin-positive spines which are received the inputs from the thalamus, was substantially high both in apical and basal dendrites. Thus, the difference in spine turnover rate between apical and basal dendrites was attributed to the stability of gephyrin-negative spines. Since the apical and basal dendrites are reported to receive the inputs from different sources, these results suggest that the regulation of spine dynamics is different between the spines which receive the different inputs.
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