Investigation of schizophrenia-like behavioral phenotypes in mice with temporal regulation of calcineurin activity
| Project/Area Number |
15K18379
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
Nakao Akito 藤田保健衛生大学, 総合医科学研究所, 助教 (30748926)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神疾患 / モデルマウス / 行動解析 |
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| Outline of Final Research Achievements |
Forebrain-specific calcineurin knockout mice show schizophrenia-like behavioral phenotypes such as impaired working memory and increased locomotor activity. In the present study, we examined the effects of the change of calcineurin activity during the developmental stage using tetracycline-regulated gene expression system. Behavioral analyses suggest that calcineurin activity after the developmental stage may be involved in increased locomotor activity.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Decroased brain pH as a shared endophenotype of psychiatric disorders2018
Author(s)
Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T
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Journal Title
Neuropsychopharmacology
Volume: 43
Pages: 459-468
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.2016
Author(s)
S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
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Journal Title
Mol Pharmacol.
Volume: 89(3)
Pages: 348-363
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering2015
Author(s)
Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y
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Journal Title
Pflugers Archiv - European Journal of Physiology
Volume: 467
Pages: 737-752
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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