• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of schizophrenia-like behavioral phenotypes in mice with temporal regulation of calcineurin activity

Research Project

Project/Area Number 15K18379
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionFujita Health University

Principal Investigator

Nakao Akito  藤田保健衛生大学, 総合医科学研究所, 助教 (30748926)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords精神疾患 / モデルマウス / 行動解析
Outline of Final Research Achievements

Forebrain-specific calcineurin knockout mice show schizophrenia-like behavioral phenotypes such as impaired working memory and increased locomotor activity. In the present study, we examined the effects of the change of calcineurin activity during the developmental stage using tetracycline-regulated gene expression system. Behavioral analyses suggest that calcineurin activity after the developmental stage may be involved in increased locomotor activity.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Decreased brain pH as a shared endophenotype of psychiatric disorders.2018

    • Author(s)
      Hagihara H et al.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Issue: 3 Pages: 459-468

    • DOI

      10.1038/npp.2017.167

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.2017

    • Author(s)
      Nakao A et al.
    • Journal Title

      Mol. Brain

      Volume: 10 Issue: 1 Pages: 60-67

    • DOI

      10.1186/s13041-017-0339-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds2016

    • Author(s)
      S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
    • Journal Title

      Mol Pharmacol

      Volume: 89(3) Issue: 3 Pages: 348-363

    • DOI

      10.1124/mol.115.102863

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.2015

    • Author(s)
      Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y
    • Journal Title

      Pflugers Arch

      Volume: 467 Issue: 4 Pages: 737-752

    • DOI

      10.1007/s00424-014-1555-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice2015

    • Author(s)
      Akito Nakao, Takafumi Miki, Hirotaka Shoji, Miyuki Nishi, Hiroshi Takeshima, Tsuyoshi Miyakawa, Yasuo Mori
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 9 Pages: 141-141

    • DOI

      10.3389/fnbeh.2015.00141

    • NAID

      120005848244

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 統合失調症モデルSchnurri-2ノックアウトマウスの歯状回顆粒細胞における三次元電子顕微鏡解析2017

    • Author(s)
      中尾章人、高雄啓三、大平耕司、宮崎直幸、村田和義、宮川剛
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Three-dimensional analysis of dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia2016

    • Author(s)
      Nakao Akito, Takao Keizo, Ohira Koji, Miyazaki Naoyuki, Murata Kazuyoshi, Miyakawa Tsuyoshi
    • Organizer
      Society for Neuroscience's 46th annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional analysis of dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia2016

    • Author(s)
      Nakao Akito, Takao Keizo, Ohira Koji, Miyazaki Naoyuki, Murata Kazuyoshi, Miyakawa Tsuyoshi
    • Organizer
      15th Annual Molecular and Cellular Cognition Society Symposium and Poster Session
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional analysis of morphological changes in dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia2016

    • Author(s)
      Nakao Akito, Takao Keizo, Ohira Koji, Miyazaki Naoyuki, Murata Kazuyoshi, Miyakawa Tsuyoshi
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional analysis of morphological changes in dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia2016

    • Author(s)
      Nakao Akito, Takao Keizo, Ohira Koji, Miyazaki Naoyuki, Murata Kazuyoshi, Miyakawa Tsuyoshi
    • Organizer
      46th Annual Meeting of Japanese Society of Neuropsychopharmacology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
  • [Presentation] BARPノックアウトマウスの網羅的行動解析2015

    • Author(s)
      中尾 章人、昌子 浩孝、森 泰生、宮川 剛
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein (BARP) knockout mice2015

    • Author(s)
      Akito Nakao, Takafumi Miki, Hirotaka Shoji, Yasuo Mori, Tsuyoshi Miyakawa
    • Organizer
      The Society for Neuroscience 45th Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein (BARP) knockout mice2015

    • Author(s)
      Akito Nakao, Takafumi Miki, Hirotaka Shoji, Yasuo Mori, Tsuyoshi Miyakawa
    • Organizer
      14th Annual Molecular and Cellular Cognition Society Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規カルシウムチャネル結合分子BARPは精神疾患様の行動異常に関与する2015

    • Author(s)
      中尾 章人 、昌子 浩孝 、森 泰生 、宮川 剛
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi