| Project/Area Number |
15K18388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 麻酔 / 周術期管理 / ラット / 実験動物福祉 / Refinement / 麻酔・鎮痛 / 麻酔薬 / 術後免疫応答 / 組織修復 |
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| Outline of Final Research Achievements |
The appropriate anesthesia is essential part of animal experimentation, in terms of laboratory animal welfare and reliability of experimental data. In the present study, we assessed the pharmacological properties of various anesthetic protocols during perioperative period in rat. Each anesthesia showed different properties during operative period. In addition, selection of anesthesia influenced the post-surgical pain level, inflammatory cytokines expressions, and wound healing process. Present findings provide the basic information for the standardization of surgical anesthesia, and contribute to the improvement of perioperative care in rat.
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