Molecular mechanism of tumour malignancy via exosomes

• Project/Area Number: 15K18424
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: Daisuke Hoshino 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技幹・主任研究員 (30571434)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: がん / 浸潤 / 細胞運動 / エクソソーム

Outline of Final Research Achievements

Here, I identified tumour malignancy promoting exosome cargoes using cell biology and mathematical modeling. First, I identified the proteins that is activated by exosomes. Next, to visualized the molecular interactions between these proteins, we performed network analysis.
Finally, I identified multiple key proteins by statistical analysis and confirmed these proteins regulate tumour malignancies in cell biology level.