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Analysis of cell-cell communication using comparison of gene co-expression for different tissues

Research Project

Project/Area Number 15K18464
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field System genome science
Research InstitutionTohoku University

Principal Investigator

Obayashi Takeshi  東北大学, 情報科学研究科, 准教授 (50397048)

Research Collaborator Kinoshita Kengo  東北大学, 大学院情報科学研究科, 教授 (60332293)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords遺伝子共発現 / ネットワーク生物学 / シロイヌナズナ / データベース / 共発現データベース / ゲノム進化
Outline of Final Research Achievements

Cell functions are composed of the individual functions of many genes. Gene network analysis is widely used to estimate the functional combination of genes.
Similarly with protein-protein interaction network analysis, gene co-expression network analysis, which is a similarity of gene expression profiles, is widely used as network analysis. In this study, I have developed a methodology to compare and integrate multiple gene co-expression networks among multiple tissues of a model plant, Arabidopsis. The results based on the new methodologies in this study were available in a plant co-expression database, ATTED-II [ http://atted.jp/ ].

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] ATTED-II in 2018: A Plant Coexpression Database based on Investigation of Statistical Property of the Mutual Rank Index.2018

    • Author(s)
      Obayashi T, Aoki Y, Tadaka S, Kagaya Y, Kinoshita K.
    • Journal Title

      Plant Cell Physiology

      Volume: 59 Issue: 1 Pages: e3-e3

    • DOI

      10.1093/pcp/pcx191

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATTED-II in 2016: a plant coexpression database towards lineage-specific coexpression.2016

    • Author(s)
      Aoki Y, Okamura Y, Tadaka S, Kinoshita K, Obayashi T.
    • Journal Title

      Plant Cell Physiology

      Volume: 57 Issue: 1 Pages: e5-e5

    • DOI

      10.1093/pcp/pcv165

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ALCOdb: Gene Coexpression Database for Microalgae.2016

    • Author(s)
      Aoki Y, Okamura Y, Ohta H, Kinoshita K, Obayashi T.
    • Journal Title

      Plant Cell Physiology

      Volume: 57 Issue: 1 Pages: e3-e3

    • DOI

      10.1093/pcp/pcv190

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of gene coexpression profiles and construction of conserved gene networks to find functional modules.2015

    • Author(s)
      Okamura Y, Obayashi T, Kinoshita K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132039-e0132039

    • DOI

      10.1371/journal.pone.0132039

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A revised coexpression calculation procedure in ATTED-II version 9 with batch-normalization and bagging methods.2018

    • Author(s)
      Takeshi Obayashi, Yuichi Aoki and Kengo Kinoshita
    • Organizer
      the 59th Annual Meeting of the Japanese Society of Plant Physiologists
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sample Alignment of Different Species toward Species-Specific Coexpression Analyses2017

    • Author(s)
      Takeshi Obayashi, Yuichi Aoki, Shu Tadaka, Yasunobu Okamura, Kengo Kinoshita
    • Organizer
      the 58th Annual Meeting of the Japanese Society of Plant Physiologists
    • Related Report
      2017 Annual Research Report
  • [Presentation] Impact of Evolutionary Age on Gene Coexpression Network and Gene Functional Relationship2016

    • Author(s)
      Yuichi Aoki, Takeshi Obayashi, Kengo Kinoshita
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Gene age determines the fundamental structure of the gene coexpression network.2016

    • Author(s)
      Yuichi Aoki, Takeshi Obayashi, Kengo Kinoshita
    • Organizer
      Intelligent Systems for Molecular Biology 2016
    • Place of Presentation
      Orlando, Florida, U.S.A
    • Year and Date
      2016-07-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Meta-analysis of gene coexpression in ATTED-II toward species-specific coexpression analyses2016

    • Author(s)
      大林武,青木裕一,岡村容伸,田高周,木下賢吾
    • Organizer
      日本植物生理学会年会
    • Place of Presentation
      岩手大学(岩手)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Remarks] 植物の遺伝子共発現データベース ATTED-II

    • URL

      http://atted.jp

    • Related Report
      2016 Research-status Report
  • [Remarks] 微細藻類の遺伝子共発現データベース ALCOdb

    • URL

      http://alcodb.jp

    • Related Report
      2016 Research-status Report
  • [Remarks] 植物の遺伝子共発現データベースATTED-II

    • URL

      http://atted.jp

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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