Elucidation of the mechanism underlying the formation of neuromuscular synapse

Research Project

Project/Area Number	15K18500
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Functional biochemistry
Research Institution	The University of Tokyo
Principal Investigator	Ueta Ryo 東京大学, 医科学研究所, 助教 (10445025)
Research Collaborator	NAGATOISHI Satoru 東京大学, 医科学研究所, 特任准教授 (30550248)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	神経筋シナプス / 神経筋疾患 / シグナル伝達 / 神経科学
Outline of Final Research Achievements	Neuromuscular Junction (NMJ) is an essential synapse between motor neuron and skeletal muscle. The NMJ formation requires muscle specific receptor kinase MuSK and "NMJ formation signal" that is driven by the activation of MuSK. To elucidate the molecular mechanisms underlying NMJ formation, we have constructed the high-throughput screening system and identified candidate molecules that are involved in "NMJ formation signal."