Biological role of galectin-GalFuc glycoepitope interaction in species-species interaction
Project/Area Number |
15K18506
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
|
Research Institution | Josai University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ガレクチン / 糖鎖 / 線虫 / 寄生虫 / Galactoseβ1-4Fucose / 種間相互作用 |
Outline of Final Research Achievements |
Parasitic nematodes infection affects more than 1 billion people worldwide and remains as a serious health problem in the world. In this study, the effect of galectin-2 on (parasitic) nematodes was investigated mainly using a free-living nematode C. elegans as a model. It was found that galectin-2 interacts with a nematode specific GalFuc glyco-epitope and suppresses the growth of C. elegans, and furthermore, the existence of the GalFuc epitope in various parasitic nematodes. These results suggest the possibility that galectin-2 suppresses various parasitic nematodes infection through interaction with the GalFuc epitope.
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Report
(4 results)
Research Products
(7 results)